Rat Testicular Mitochondrial Antioxidant Defence System and its Modulation By Aging

被引：0
作者：
D. K. Sahoo
Anita Roy
G. B. N. Chainy
机构：
[1] Utkal University,Department of Zoology
[2] Utkal University,Department of Biotechnology
来源：
Acta Biologica Hungarica | 2008年 / 59卷
关键词：
Aging; rat; testes; mitochondria; reactive oxygen species; oxidative stress;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Accumulation of oxidative damage caused by reactive oxygen species (ROS) underlies fundamental changes found during aging. In the present study, age related effect on testicular mitochondrial oxidant generation and antioxidant defence profile was investigated in Wistar rats at 3 months (young adults), 12 months (old adults) and 24 months (senescent animals) of age. Mitochondrial oxidative stress parameters viz., lipid peroxidation (LPx), protein carbonylation, hydrogen peroxide (H202) generation and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR), levels of total, oxidized (GSSG) and reduced glutathione (GSH) were studied to find out their roles in maintenance of mitochondrial glutathione redox pool as a function of age. Increased levels of LPx, H202 and decreased GSH content accompanied by a decline in activities of SOD, GPx and GR with advancing age suggest that antioxidant defense profile of testicular mitochondria exhibit age related alterations which might play a critical role in regulating physiological functions of the testis such as steroidogenesis and spermatogenesis.
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页码：413 / 424
页数：11
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