Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation

被引：105
作者：
Huang C.-J. [1 ]
McAllister M.J. [2 ]
Slusher A.L. [1 ,3 ]
Webb H.E. [4 ]
Mock J.T. [1 ]
Acevedo E.O. [3 ]
机构：
[1] Exercise Biochemistry Laboratory, Department of Exercise Science and Health Promotion, Florida Atlantic University, 777 Glades Road, FH11A-126B, Boca Raton, 33431, FL
[2] Department of Kinesiology, Mississippi State University, Starkville, MS
[3] Department of Kinesiology and Health Sciences, Virginia Commonwealth University, Richmond, VA
[4] Department of Kinesiology, Texas A&M University–Corpus Christi, Corpus Christi, TX
来源：
Sports Medicine - Open | 2015年 / 1卷 / 1期
关键词：
Aerobic Exercise; Caloric Restriction; Nitric Oxide; Oxidative Stress; Resveratrol;
D O I：
10.1186/s40798-015-0031-y
中图分类号：
学科分类号：
摘要：
Obesity-related oxidative stress, the imbalance between pro-oxidants and antioxidants (e.g., nitric oxide), has been linked to metabolic and cardiovascular disease, including endothelial dysfunction and atherosclerosis. Reactive oxygen species (ROS) are essential for physiological functions including gene expression, cellular growth, infection defense, and modulating endothelial function. However, elevated ROS and/or diminished antioxidant capacity leading to oxidative stress can lead to dysfunction. Physical activity also results in an acute state of oxidative stress. However, it is likely that chronic physical activity provides a stimulus for favorable oxidative adaptations and enhanced physiological performance and physical health, although distinct responses between aerobic and anaerobic activities warrant further investigation. Studies support the benefits of dietary modification as well as exercise interventions in alleviating oxidative stress susceptibility. Since obese individuals tend to demonstrate elevated markers of oxidative stress, the implications for this population are significant. Therefore, in this review our aim is to discuss (i) the role of oxidative stress and inflammation as associated with obesity-related diseases, (ii) the potential concerns and benefits of exercise-mediated oxidative stress, and (iii) the advantageous role of dietary modification, including acute or chronic caloric restriction and vitamin D supplementation. © 2015, Huang et al.
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