PADMA-28, a traditional Tibetan herbal preparation inhibits the respiratory burst in human neutrophils, the killing of epithelial cells by mixtures of oxidants and pro-inflammatory agonists and peroxidation of lipids

被引：30

作者：

Ginsburg I. ^{[1
]}

Sadovnik M. ^{[1
]}

Sallon S. ^{[1
]}

Milo-Goldzweig I. ^{[1
]}

Mechoulam R. ^{[1
]}

Breuer A. ^{[1
]}

Gibbs D. ^{[1
]}

Varani J. ^{[1
]}

Roberts S. ^{[1
]}

Cleator E. ^{[1
]}

Singh N. ^{[1
]}

机构：

[1] Dept. of Oral Biol. Hebrew Univ., Hadassah School of Dental Medicine, Jerusalem

来源：

InflammoPharmacology | 1999年 / 7卷 / 1期

关键词：

Anti-oxidants; Cytolytic cocktail; Herbal preparation; Oxidative stress;

D O I：

10.1007/s10787-999-0025-9

中图分类号：

学科分类号：

摘要：

Both aqueous and methanolic fractions derived from the Tibetan preparation PADMA-28 (a mixture of 22 plants) used as an anti- atherosclerotic agent, and which is non-cytolytic to a variety of mammalian cells, were found to strongly inhibit (1) the killing of epithelial cells in culture induced by 'cocktails' comprising oxidants, membrane perforating agents and proteinases; (2) the generation of luminol-dependent chemiluminescence in human neutrophils stimulated by opsonized bacteria; (3) the peroxidation of intralipid (a preparation rich in phopholipids) induced in the presence of copper; and (4) the activity of neutrophil elastase. It is proposed that PADMA-28 might prove beneficial for the prevention of cell damage induced by synergism among pro-inflammatory agonists which is central in the initiation of tissue destruction in inflammatory and infectious conditions.

引用

页码：47 / 62

页数：15

共 48 条

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