Recent developments in chromatographic purification of biopharmaceuticals

被引：0
作者：
Anurag S. Rathore
Devashish Kumar
Nikhil Kateja
机构：
[1] Indian Institute of Technology,Department of Chemical Engineering, DBT Center of Excellence for Biopharmaceutical Technology
[2] Delhi,undefined
来源：
Biotechnology Letters | 2018年 / 40卷
关键词：
Biopharmaceutical manufacturing; Chromatography; Continuous chromatography; Downstream processing; Purification;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Over the last several decades, researchers have time and again proposed use of non-chromatographic methods for processing of biotherapeutic products. However, chromatography continues to be the backbone of downstream processing, particularly at process scale. There are many reasons for this, critical ones being the unparalleled scalability, robustness, and selectivity that process chromatography offers over its peers. It is no surprise then that process chromatography has been a topic of major developments in resin matrix, ligand chemistry, modalities, high throughput process development, process modelling, and approaches for control. In this review, we attempt to summarize major developments in the above-mentioned areas. Greater significance has been given to advancements in the last 5 years (2013–2017).
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页码：895 / 905
页数：10
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