Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer

[1] Lee JM(2014)PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies Ann Oncol 25 32-40

[2] Ledermann JA(2014)Beyond breast and ovarian cancers: PARP inhibitors for BRCA mutation-associated and BRCA-like solid tumors Front Oncol 4 42-861

[3] Kohn EC(2014)Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial Lancet Oncol 15 852-967

[4] O’Sullivan CC(2008)GammaH2AX and cancer Nat Rev Cancer 8 957-20312

[5] Moon DH(2003)Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes J Biol Chem 278 20303-895

[6] Kohn EC(2000)A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr Biol 10 886-7758

[7] Lee JM(2007)ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks Oncogene 26 7749-181

[8] Ledermann J(2009)Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression DNA Repair (Amst) 8 170-40

[9] Harter P(2013)gammaH2AX as a marker of DNA double strand breaks and genomic instability in human population studies Mutat Res 753 24-4542

[10] Gourley C(2010)Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers Clin Cancer Res 16 4532-5634

[1] Lee JM(2014)PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies Ann Oncol 25 32-40

[2] Ledermann JA(2014)Beyond breast and ovarian cancers: PARP inhibitors for BRCA mutation-associated and BRCA-like solid tumors Front Oncol 4 42-861

[3] Kohn EC(2014)Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: a preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial Lancet Oncol 15 852-967

[4] O’Sullivan CC(2008)GammaH2AX and cancer Nat Rev Cancer 8 957-20312

[5] Moon DH(2003)Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes J Biol Chem 278 20303-895

[6] Kohn EC(2000)A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr Biol 10 886-7758

[7] Lee JM(2007)ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks Oncogene 26 7749-181

[8] Ledermann J(2009)Recovery of deficient homologous recombination in Brca2-depleted mouse cells by wild-type Rad51 expression DNA Repair (Amst) 8 170-40

[9] Harter P(2013)gammaH2AX as a marker of DNA double strand breaks and genomic instability in human population studies Mutat Res 753 24-4542

[10] Gourley C(2010)Histone gammaH2AX and poly(ADP-ribose) as clinical pharmacodynamic biomarkers Clin Cancer Res 16 4532-5634