Histamine augments collagen content via H1 receptor stimulation in cultures of myofibroblasts taken from wound granulation tissue

被引：0
作者：
Monika Wolak
Ewa Bojanowska
Teresa Staszewska
Lucyna Piera
Jacek Szymański
Jacek Drobnik
机构：
[1] Department of Behavioral Pathophysiology,
[2] Chair of General and Experimental Pathology,undefined
[3] Medical University of Lodz,undefined
[4] Laboratory of Connective Tissue Metabolism,undefined
[5] Department of Pathophysiology,undefined
[6] Chair of General and Experimental Pathology Medical University of Lodz,undefined
[7] Central Scientific Laboratory,undefined
[8] Medical University of Lodz,undefined
来源：
Molecular and Cellular Biochemistry | 2021年 / 476卷
关键词：
Collagen; Cell culture; Histamine; Myofibroblast; Fibrosis; Healing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The inflammatory reaction influences the deposition of collagen within wound granulation tissue. The aim of the present study is to determine whether histamine acting directly on myofibroblasts derived from wound granulation tissue may influence collagen deposition. It also identifies the histamine receptor involved in this process. The experiments were carried out on cells isolated from the granulation tissue of a wound model (a polypropylene net inserted subcutaneously to rats) or intact rat skin. Collagen content was measured following the addition of different concentrations of histamine and treatment with histamine receptor antagonists (ketotifen – H1 inhibitor, ranitidine – H2 inhibitor) and a histamine receptor H1 agonist (2-pyridylethylamine dihydrochloride).
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页码：1083 / 1092
页数：9
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