Modulation of Ionotropic Glutamate Receptor Channels

被引：0
作者：
L. Köles
K. Wirkner
P. Illes
机构：
[1] University of Leipzig,Rudolf
[2] Semmelweis University,Boehm
来源：
Neurochemical Research | 2001年 / 26卷
关键词：
Ionotropic glutamate receptors; NMDA receptor; AMPA receptor; adenosine A; receptor; phosphorylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example, mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.
引用
收藏
页码：925 / 932
页数：7
相关论文
共 339 条
  • [11] Yamaguchi S.(1993)A synaptic model of memory: Long-term potentiation in the hippocampus Nature 361 31-39
  • [12] Kawabata S.(1992)Molecular diversity of glutamate receptors and implications for brain function Science 258 597-603
  • [13] Okada M.(1988)Glutamate neurotoxicity and diseases of the nervous system Neuron 1 623-634
  • [14] Dingledine R.(1991)Excitatory amino acid receptors, natural membrane phospholipid metabolism and neurological disorders Brain Res. Rev. 16 171-191
  • [15] Borges K.(1994)Excitatory amino acids as a final common pathway for neurological disorders New Engl. J. Med. 330 613-622
  • [16] Bowie D.(1998)The role of glutamatergic transmission in the pathophysiology of alcoholism Annu. Rev. Med. 49 173-184
  • [17] Traynelis S. F.(2000)Glutamate-mediated transmission, alcohol, and alcoholism Neurochem. Int. 37 509-533
  • [18] Watkins J. C.(1993)Molecular characterization of the family of the Nmethyl-D-aspartate receptor subunits J. Biol. Chem. 268 2836-2843
  • [19] Krogsgaard-Larsen P.(1996)NMDA receptors: From genes to channels Trends Pharmacol. Sci. 17 348-355
  • [20] Honore T.(1996)The glycine binding site of the N-methyl-D-aspartate receptor subunit NR1: Identification of novel determinants of co-agonist potentiation in the extracellular M3-M4 loop region Proc. Natl. Acad. Sci. USA 93 6031-6036
12345678910