Modulation of Ionotropic Glutamate Receptor Channels

被引：0
作者：
L. Köles
K. Wirkner
P. Illes
机构：
[1] University of Leipzig,Rudolf
[2] Semmelweis University,Boehm
来源：
Neurochemical Research | 2001年 / 26卷
关键词：
Ionotropic glutamate receptors; NMDA receptor; AMPA receptor; adenosine A; receptor; phosphorylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example, mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.
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页码：925 / 932
页数：7
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