Induction of differentiation by wild-type p53 gene in a human glioma cell line

被引：0
|
作者：
Takashi Kokunai
Atsufumi Kawamura
Norihiko Tamaki
机构：
[1] Kobe University School of Medicine,Department of Neurosurgery
来源：
Journal of Neuro-Oncology | 1997年 / 32卷
关键词：
glioma; differentiation; p53 gene; cell cycle; p21;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Wild-type human p53 gene was transfected into the human glioma cell line T-98G. Transfectants were then isolated and characterizedfor growth potential and differentiation phenotype. Growth suppression,overexpression of GFAP, and accumulation in G1phase were more commonly observed in transfectants than inT-98G cells. p21WAF1/CIP1 wasoverexpressed in transfectants, and the binding of PCNA and CDK 2 top21WAF1/CIP1 were increased in transfectants. These results suggested the roles of p21WAF1/CIP1, PCNA,and CDK 2 in regulation of differentiation in glioma cells and the gene transfer of wild-type p53 may be effective forthe control of glial differentiation in glioma cells.
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页码：125 / 133
页数：8
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