Synthesis, characterization, and antihyperglycemic activity of novel oxazolidine derivatives

被引：0

作者：

Theivendren Panneer Selvam

Palanirajan Vijayaraj Kumar

Parthasarathi Ramu

Arumugam Siva Kumar

机构：

[1] Srinivas College of Pharmacy,Department of Pharmaceutical Chemistry

[2] UCSI (University College Sadaya International) University,Faculty of Pharmaceutical Sciences

[3] IITMadras,Department of Biotechnology

[4] VIT University,School of Bio Science and Technology

来源：

Archives of Pharmacal Research | 2011年 / 34卷

关键词：

Oxazolidine; Aromatic aldehydes substitution; Antihyperglycemic activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A number of compounds have been prepared in order to improve pharmacological roles of antihyperglycemic activity. In the present paper, a series of 3-benzyl-2-(4′-substituted phenyl)-4(5H)-(4″-nitrophenyl amino)-1,3-oxazolidines (6a–e) were tested against hyperglycemia. Their antihyperglycemic activity was evaluated by streptozotocin (STZ) and sucrose-loaded (SLM) models. Compounds 6a, b, c, d, and e displayed significant reductions in blood glucose in the streptozotocin and sucrose loaded rat models. The purity of the synthesized compounds was characterized by means of IR, 1H-NMR, mass spectral and elemental analysis.

引用

页码：887 / 891

页数：4

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