Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats

被引：0
作者：
N. S. Sapronov
Yu. O. Fedotova
E. I. Malygina
机构：
[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2004年 / 137卷
关键词：
8-OH-DPAT; passive avoidance; plus-maze; behavior; estrogens; pharmacotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17β-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17β-estradiol improved performance of the conditioned passive avoidance response.
引用
收藏
页码：43 / 46
页数：3
相关论文
共 28 条
  • [21] Effect of growth hormone and estrogen administration on hepatocyte alterations in old ovariectomized female wistar rats
    Castillo, C
    Salazar, V
    Ariznavarreta, C
    Vara, E
    Tresguerres, JAF
    ENDOCRINE, 2005, 26 (01) : 11 - 18
  • [22] Effect of growth hromone and estrogen administration on hepatocyte alterations in old ovariectomized female wistar rats
    Carmen Castillo
    Veronica Salazar
    Carmen Ariznavarreta
    Elena Vara
    Jesus A. F. Tresguerres
    Endocrine, 2005, 26 : 11 - 18
  • [23] Different effects of vitamin D hormone treatment on depression-like behavior in the adult ovariectomized female rats
    Fedotova, Julia
    Dudnichenko, Tatyana
    Kruzliak, Peter
    Puchavskaya, Zhanna
    BIOMEDICINE & PHARMACOTHERAPY, 2016, 84 : 1865 - 1872
  • [24] Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats
    Butkevich, I. P.
    Mikhailenko, V. A.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2018, 165 (02) : 209 - 212
  • [25] Effect of Fluoxetine in Prenatal Period on Nociceptive System Reactivity and Psychoemotional Behavior in Young Female Rats
    I. P. Butkevich
    V. A. Mikhailenko
    Bulletin of Experimental Biology and Medicine, 2018, 165 : 209 - 212
  • [26] Transgenerational effect of prenatal stress on behavior and lipid peroxidation in brain structures of female rats during the estral cycle
    Vyushina, A. V.
    Pritvorova, A., V
    Pivina, S. G.
    Ordyan, N. E.
    VAVILOVSKII ZHURNAL GENETIKI I SELEKTSII, 2024, 28 (04): : 387 - 397
  • [27] Infusion of low dose glyceryl trinitrate has no consistent effect on burrowing behavior, running wheel activity and light sensitivity in female rats
    Christensen, Sarah L. T.
    Petersen, Steffen
    Sorensen, Dorte B.
    Olesena, Jes
    Jansen-Olesen, Inger
    JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2016, 80 : 43 - 50
  • [28] 17β-Estradiol replacement in young, adult and middle-aged female ovariectomized rats promotes improvement of spatial reference memory and an antidepressant effect and alters monoamines and BDNF levels in memory- and depression-related brain areas
    Kiss, Agata
    Delattre, Ana Marcia
    Pereira, Sofia I. R.
    Carolino, Ruither G.
    Szawka, Raphael E.
    Anselmo-Franci, Janete A.
    Zanata, Silvio M.
    Ferraz, Anete C.
    BEHAVIOURAL BRAIN RESEARCH, 2012, 227 (01) : 100 - 108
123