Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats

被引：0
作者：
N. S. Sapronov
Yu. O. Fedotova
E. I. Malygina
机构：
[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2004年 / 137卷
关键词：
8-OH-DPAT; passive avoidance; plus-maze; behavior; estrogens; pharmacotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17β-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17β-estradiol improved performance of the conditioned passive avoidance response.
引用
收藏
页码：43 / 46
页数：3
相关论文
共 28 条
  • [1] Modulatory effect of 8-OH-DPAT on behavior of ovariectomized female rats
    Sapronov, NS
    Fedotova, YO
    Malygina, EI
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2004, 137 (01) : 43 - 46
  • [2] Effects of 8-OH-DPAT and NAN-190 on Anxious-Depressive-Like Behavior of Female Rats during the Estrous Cycle
    Fedotova, Yu. O.
    Ordyan, N. E.
    BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2010, 150 (02) : 165 - 167
  • [3] Effects of 8-OH-DPAT and NAN-190 on Anxious-Depressive-Like Behavior of Female Rats during the Estrous Cycle
    Yu. O. Fedotova
    N. E. Ordyan
    Bulletin of Experimental Biology and Medicine, 2010, 150 : 165 - 167
  • [4] 8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats
    Cai, Yongjian
    Zhang, Xinyue
    Jiang, Tianyi
    Zhong, Haocheng
    Han, Xingchen
    Ma, Rui
    Wu, Ruiyong
    JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2022, 208 (04): : 467 - 477
  • [5] Peripheral 8-OH-DPAT and scopolamine infused into the frontal cortex produce passive avoidance retention impairments in rats
    Santucci, AC
    Shaw, C
    NEUROBIOLOGY OF LEARNING AND MEMORY, 2003, 79 (02) : 136 - 141
  • [6] Facilitation by 8-OH-DPAT of passive avoidance performance in rats after inactivation of 5-HT1A receptors
    Otano, A
    García-Osta, A
    Ballaz, S
    Frechilla, D
    Del Río, J
    BRITISH JOURNAL OF PHARMACOLOGY, 1999, 128 (08) : 1691 - 1698
  • [7] EFFECTS OF 8-OH-DPAT AND BUSPIRONE IN A PASSIVE-AVOIDANCE TEST AND IN THE ELEVATED PLUS-MAZE TEST IN RATS
    KLINT, T
    BEHAVIOURAL PHARMACOLOGY, 1991, 2 (06): : 481 - 489
  • [8] DEVELOPMENT OF TOLERANCE TO 8-OH-DPAT INDUCED BLOCKADE OF ACQUISITION OF A PASSIVE-AVOIDANCE RESPONSE
    JACKSON, DM
    BENGTSSON, A
    JOHANSSON, C
    CORTIZO, L
    ROSS, SB
    NEUROPHARMACOLOGY, 1994, 33 (08) : 1003 - 1009
  • [9] Effects of fenfluramine, 8-OH-DPAT, and tryptophan-enriched diet on the high-ethanol intake by rats bred for susceptibility to stress
    West, Charles H. K.
    Boss-Williams, Katherine A.
    Weiss, Jay M.
    ALCOHOL, 2011, 45 (08) : 739 - 749
  • [10] Effects of bilateral lesions in thalamic reticular nucleus and orbitofrontal cortex in a T-maze perseverative model produced by 8-OH-DPAT in rats
    Andrade, Pablo
    Fernandez-Guasti, Alonso
    Carrillo-Ruiz, Jose D.
    Ulloa, Rosa E.
    Ramirez, Ylian
    Reyes, Rebeca
    Jimenez, Fiacro
    BEHAVIOURAL BRAIN RESEARCH, 2009, 203 (01) : 108 - 112
123