Identifying peptide ligands for cell surface receptors using cell-growth-on-bead assay and one-bead one-compound combinatorial library

被引：0
作者：
Derick H. Lau
Linlang Guo
Ruiwu Liu
Aimin Song
Chunkui Shao
Kit S. Lam
机构：
[1] University of California Davis Cancer Center,Department of Internal Medicine and Veteran Administration Northern California Health System, Division of Hematology and Oncology
来源：
Biotechnology Letters | 2002年 / 24卷
关键词：
cell-growth-on-bead assay; integrin; lung cancer; one-bead one-compound combinatorial library; peptide ligand;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A cell-growth-on-bead assay was used to screen one-bead, one-compound combinatorial libraries for peptide ligands that attract attachment and growth of human lung cancer cells. A consensus cyclic peptide sequence, d-cys-l-asn-l-gly-l-arg-l-gly-l-glu-l-gln-d-cys (cNGRGEQc), was identified as a ligand for a cell surface receptor, α3β1 integrin. This peptide ligand and its analogs have the potential to be used as diagnostic and therapeutic agents for lung cancer.
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页码：497 / 500
页数：3
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