The pathogenic role of interleukin-27 in autoimmune diabetes

被引：0
|
作者：
R. Wang
G. Han
J. Wang
G. Chen
R. Xu
L. Wang
X. Li
B. Shen
Y. Li
机构：
[1] Institute of Basic Medical Sciences,Department of Molecular Immunology
[2] Medical School of Henan University,Institute of Immunology
来源：
Cellular and Molecular Life Sciences | 2008年 / 65卷
关键词：
IL-27; autoimmune diabetes; IFN-γ; IL-17; IL-4; TGF-β; IL-10;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Interleukin (IL)-27 is an IL-12-related cytokine that can promote both anti- and pro-inflammatory immune responses. This study investigated the potential role of IL-27 in autoimmune diabetes. We detected a high level of IL-27 in diabetic NOD mice. In addition, blockade of IL-27 significantly delayed the onset of diabetic splenocyte-transferred diabetes, while IL-27-treated diabetic splenocytes promoted the onset of the disease, compared with untreated controls. Furthermore, IL-27 up-regulated pro-inflammatory cytokines IFN-γ and IL-17 and down-regulated anti-inflammatory cytokines IL-4, TGF-β, and IL-10 secreted by diabetic splenocytes. These results demonstrate a pathogenic role of IL-27 in T cell-mediated autoimmune diabetes.
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收藏
页码：3851 / 3860
页数：9
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