Phylogenetic Analysis of the Homologous Proteins of the Terminal Complement Complex Supports the Emergence of C6 and C7 Followed by C8 and C9

被引：0

作者：

Mariana Mondragón-Palomino

Daniel Piñero

Anne Nicholson-Weller

Juan P. Laclette

机构：

[1] Department of Immunology,

[2] Instituto de Investigaciones Biomédicas,undefined

[3] Universidad Nacional Autónoma de México,undefined

[4] A.P. 70228,undefined

[5] 04510 México,undefined

[6] D.F.,undefined

[7] México,undefined

[8] Department of Evolutionary Ecology,undefined

[9] Instituto de Ecología,undefined

[10] Universidad Nacional Autónoma de México,undefined

[11] México,undefined

[12] D.F.,undefined

[13] México,undefined

[14] Department of Medicine,undefined

[15] Harvard Medical School and Beth Israel Deaconess Medical Center,undefined

[16] Boston,undefined

[17] Massachusetts,undefined

[18] USA,undefined

来源：

Journal of Molecular Evolution | 1999年 / 49卷

关键词：

Key words: Evolution — Complement system — Terminal complement complex — Membrane attack complex — Perforin;

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学科分类号：

摘要：

The plasma complement system comprises several activation pathways that share a common terminal route involving the assembly of the terminal complement complex (TCC), formed by C5b–C9. The order of emergence of the homologous components of TCC (C6, C7, C8α, C8β, and C9) has been determined by phylogenetic analyses of their amino acid sequences. Using all the sequence data available for C6–C9 proteins, as well as for perforins, the results suggested that these TCC components originated from a single ancestral gene and that C6 and C7 were the earliest to emerge. Our evidence supports the notion that the ancestral gene had a complex modular composition. A series of gene duplications in combination with a tendency to lose modules resulted in successive complement proteins with decreasing modular complexity. C9 and perforin apparently are the result of different selective conditions to acquire pore-forming function. Thus C9 and perforin are examples of evolutionary parallelism.

引用

页码：282 / 289

页数：7