G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Iwachidow K(2009)Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916 J Biol Chem 284 2332-2828

Doshi LS(2003)Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation J Biol Chem 278 2824-366

Brahma MK(2008)Glucolipotoxicity: fuel excess and beta-cell dysfunction Endocr Rev 29 351-954

Sayyed SG(2008)The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice Biochem Soc Trans 36 950-258

Lin DC(2005)The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse Cell Metab 1 245-39

Zhang J(2008)Biphasic insulin secretion from freshly isolated or cultured, perifused rodent islets: comparative studies with rats and mice Metabolism 57 30-41367

Zhuang R(2011)Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo J Biol Chem 286 41359-9546

Tsujihata Y(2007)Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion J Biol Chem 282 9536-489

Ito R(2012)The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets J Pharmacol Exp Ther 340 483-540

Suzuki M(2008)Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway J Endocrinol 198 533-323

Iwachidow K(2009)Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916 J Biol Chem 284 2332-2828

Doshi LS(2003)Thrombin rapidly induces protein kinase D phosphorylation, and protein kinase C delta mediates the activation J Biol Chem 278 2824-366

Brahma MK(2008)Glucolipotoxicity: fuel excess and beta-cell dysfunction Endocr Rev 29 351-954

Sayyed SG(2008)The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice Biochem Soc Trans 36 950-258

Lin DC(2005)The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse Cell Metab 1 245-39

Zhang J(2008)Biphasic insulin secretion from freshly isolated or cultured, perifused rodent islets: comparative studies with rats and mice Metabolism 57 30-41367

Zhuang R(2011)Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo J Biol Chem 286 41359-9546

Tsujihata Y(2007)Glucose-stimulated Cdc42 signaling is essential for the second phase of insulin secretion J Biol Chem 282 9536-489

Ito R(2012)The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets J Pharmacol Exp Ther 340 483-540

Suzuki M(2008)Activation of ATP-sensitive potassium channels in rat pancreatic beta-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway J Endocrinol 198 533-323