G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1

Whiting DR(2011)IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030 Diabetes Res Clin Pract 94 311-321

Guariguata L(2006)Islet beta cell failure in type 2 diabetes J Clin Invest 116 1802-1812

Weil C(2010)Nutrient regulation of insulin secretion and beta-cell functional integrity Adv Exp Med Biol 654 91-114

Shaw J(2003)Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 173-176

Prentki M(2003)The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J Biol Chem 278 11303-11311

Nolan CJ(2003)Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors Pharmacol Toxicol 93 249-258

Newsholme P(2007)GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo Diabetes 56 1087-1094

Gaudel C(2009)Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets Diabetes 58 2607-2615

McClenaghan NH(2011)Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40 J Biol Chem 286 11890-11894

Itoh Y(2009)Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice Diabetes 58 1067-1076

Whiting DR(2011)IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030 Diabetes Res Clin Pract 94 311-321

Guariguata L(2006)Islet beta cell failure in type 2 diabetes J Clin Invest 116 1802-1812

Weil C(2010)Nutrient regulation of insulin secretion and beta-cell functional integrity Adv Exp Med Biol 654 91-114

Shaw J(2003)Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 173-176

Prentki M(2003)The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J Biol Chem 278 11303-11311

Nolan CJ(2003)Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors Pharmacol Toxicol 93 249-258

Newsholme P(2007)GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo Diabetes 56 1087-1094

Gaudel C(2009)Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets Diabetes 58 2607-2615

McClenaghan NH(2011)Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40 J Biol Chem 286 11890-11894

Itoh Y(2009)Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice Diabetes 58 1067-1076