Fragile sites in cancer: more than meets the eye

被引：0
作者：
Thomas W. Glover
Thomas E. Wilson
Martin F. Arlt
机构：
[1] University of Michigan Medical School,Thomas W. Glover is at the Department of Human Genetics; the Department of Pathology; and the Department of Pediatrics and Communicable Diseases
[2] Ann Arbor,Thomas E. Wilson is at the Department of Human Genetics; and the Department of Pathology
[3] Michigan 48109,and the Department of Pathology
[4] USA,Martin F. Arlt is at the Department of Human Genetics
[5] the Department of Pathology,undefined
[6] University of Michigan Medical School,undefined
[7] Ann Arbor,undefined
[8] Michigan 48109,undefined
[9] USA.,undefined
[10] University of Michigan Medical School,undefined
[11] Ann Arbor,undefined
[12] Michigan 48109,undefined
[13] USA.,undefined
[14] University of Michigan Medical School,undefined
[15] Ann Arbor,undefined
[16] Michigan 48109,undefined
[17] USA.,undefined
来源：
Nature Reviews Cancer | 2017年 / 17卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This Opinion article discusses recent studies that have provided new insights into the mechanisms of common fragile site instability and the resulting genomic effects, which include the generation of focal copy number alterations that affect the genomic landscape of many cancers.
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页码：489 / 501
页数：12
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  • [1] Glover TW(1984)DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes Hum. Genet. 67 136-142
  • [2] Berger C(1984)Fragile sites and predisposition to leukemia and lymphoma Cancer Genet. Cytogenet. 12 85-88
  • [3] Coyle J(1987)Fragile sites and chromosomal structural rearrangements in human leukemia and cancer Anticancer Res. 7 417-422
  • [4] Echo B(1988)Fragile sites, mutagens and genomic rearrangements in cancer Basic Life Sci. 43 11-21
  • [5] Yunis JJ(1986)Chromosomal fragile sites and cancer-specific rearrangements Blood 67 849-858
  • [6] de Braekeleer M(1985)Fragile sites and structural rearrangements in cancer Hum. Genet. 69 112-116
  • [7] Yunis JJ(2013)Identification of early replicating fragile sites that contribute to genome instability Cell 152 620-632
  • [8] Le Beau MM(1997)The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B Biochim. Biophys. Acta 1332 M65-M70
  • [9] De Braekeleer M(1996)The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers Cell 84 587-597
  • [10] Smith B(2013)Pan-cancer patterns of somatic copy number alteration Nat. Genet. 45 1134-1140
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