Synthesis, characterization and antimicrobial activities of some novel bis-chalcones

被引：0
|
作者：
Akbar Mobinikhaledi
Mehdi Kalhor
Hossein Jamalifar
机构：
[1] Arak University,Department of Chemistry
[2] Payame Noor University,Department of Chemistry
[3] Tehran University of Medical Sciences,Department of Drug and Food Control Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Bis-chalcones; Microorganisms; Antimicrobial activities;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel bis-chalcones 3a–n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, 1H and 13C NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.
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页码：1811 / 1816
页数：5
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