Synthesis, characterization and antimicrobial activities of some novel bis-chalcones

被引：0
|
作者：
Akbar Mobinikhaledi
Mehdi Kalhor
Hossein Jamalifar
机构：
[1] Arak University,Department of Chemistry
[2] Payame Noor University,Department of Chemistry
[3] Tehran University of Medical Sciences,Department of Drug and Food Control Faculty of Pharmacy
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
Bis-chalcones; Microorganisms; Antimicrobial activities;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel bis-chalcones 3a–n were synthesized in excellent yields by condensation reaction of 1,4-diacetylbenzene with various aldehydes in ethanol 96% and aqueous NaOH at room temperature. All compounds were characterized by IR, 1H and 13C NMR, UV spectroscopy and elemental analysis. The antimicrobial activities of synthesized compounds were also evaluated. The most of these compounds exhibited a good activity against Staphylococcus aureus, Escherichia coli and Candida albicans microorganisms. Some of them showed significant activities.
引用
收藏
页码：1811 / 1816
页数：5
相关论文
共 50 条
  • [21] Synthesis and Anticancer Activities of Novel Bis-chalcones Incorporating the 1,3-diphenyl-1H-pyrazole Moiety: In Silico and In Vitro Studies
    Mohamed, Magda F.
    Sroor, Farid M.
    Elsayed, Shahinda E.
    Mahrous, Karima F.
    Mageed, Lamiaa
    Hanafy, Mahmoud Khaled
    Ibrahim, Sherif A.
    Elwahy, Ahmed H. M.
    Abdelhamid, Ismail A.
    LETTERS IN DRUG DESIGN & DISCOVERY, 2022, 19 (11) : 1007 - 1021
  • [22] Synthesis, biological evaluation and molecular docking studies of a new series of bis-chalcones
    Zahra Khazaei-Poul
    Nosrat Ollah Mahmoodi
    Hossein Taherpour Nahzomi
    Research on Chemical Intermediates, 2023, 49 : 273 - 287
  • [23] Synthesis, Characterization, and Antimicrobial Potential of Some Chlorinated Benzofuran Chalcones
    Coskun, Demet
    Dalkilic, Semite
    Dalkilic, Lutfiye Kadioglu
    Coskun, Mehmet Fatih
    PROGRESS IN NUTRITION, 2021, 23
  • [24] Synthesis and study of mesomorphic properties of unsymmetrical cyclohexanone-derived bis-chalcones
    Patel, Krupa N.
    Prajapati, Ashish K.
    Kamath, Bola V.
    Bedekar, Ashutosh V.
    LIQUID CRYSTALS, 2016, 43 (06) : 729 - 734
  • [25] Synthesis and antimicrobial activity of some novel chalcones and their related compounds
    Kaithwal, Mohit Kumar
    Garg, Poonam
    Ahmad, Shamim
    ORIENTAL JOURNAL OF CHEMISTRY, 2009, 25 (04) : 935 - 943
  • [26] Synthesis of some novel chalcones, pyrazolines, aminopyrimidines and their antimicrobial study
    Solankee, Anjani
    Patel, Rajnikant
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2014, 53 (11): : 1448 - 1453
  • [27] Design, synthesis, and molecular docking study of novel quinoline-based bis-chalcones as potential antitumor agents
    Insuasty, Daniel
    Garcia, Stephanie
    Abonia, Rodrigo
    Insuasty, Braulio
    Quiroga, Jairo
    Nogueras, Manuel
    Cobo, Justo
    Borosky, Gabriela L.
    Laali, Kenneth K.
    ARCHIV DER PHARMAZIE, 2021, 354 (09)
  • [28] Discovery of bis-chalcones and bis-pyrimidines as potential urease inhibitors: from synthesis to computational insights
    Naeem, Nafeesa
    Zaib, Sumera
    Mughal, Ehsan Ullah
    Othman, Gehan Ahmed
    Sadiq, Amina
    Rana, Nehal
    FUTURE MEDICINAL CHEMISTRY, 2025,
  • [29] Synthesis of chalcones and their antimicrobial and drug potentiating activities
    dos Santos, Antonia Thassya Lucas
    de Araujo-Neto, Jose Bezerra
    da Silva, Maria Milene Costa
    da Silva, Maria Elenilda Paulino
    Carneiro, Joara Nalyda Pereira
    Fonseca, Victor Juno Alencar
    Coutinho, Henrique Douglas Melo
    Bandeira, Paulo Nogueira
    dos Santos, Helcio Silva
    Mendes, Francisco Rogenio da Silva
    Sales, Debora Lima
    Morais-Braga, Maria Flaviana Bezerra
    MICROBIAL PATHOGENESIS, 2023, 180
  • [30] Synthesis, characterization, and antimicrobial and antioxidant activities of novel bis-isatin carbohydrazone derivatives
    Kiran, Gangarapu
    Sarangapani, Manda
    Gouthami, Thumma
    Reddy, Anreddy Rama Narsimha
    TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, 2013, 95 (03): : 367 - 378
12345