HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C

被引：0
|
作者：
Rasmi Thomas
Richard Apps
Ying Qi
Xiaojiang Gao
Victoria Male
Colm O'hUigin
Geraldine O'Connor
Dongliang Ge
Jacques Fellay
Jeffrey N Martin
Joseph Margolick
James J Goedert
Susan Buchbinder
Gregory D Kirk
Maureen P Martin
Amalio Telenti
Steven G Deeks
Bruce D Walker
David Goldstein
Daniel W McVicar
Ashley Moffett
Mary Carrington
机构：
[1] Cancer and Inflammation Program,Department of Pathology
[2] Laboratory of Experimental Immunology,Department of Molecular Microbiology & Immunology
[3] SAIC-Frederick,Division of Cancer Epidemiology and Genetics
[4] Inc.,San Francisco Department of Public Health
[5] NCI-Frederick,Department of Epidemiology
[6] Cambridge University,undefined
[7] Cancer and Inflammation Program,undefined
[8] Laboratory of Experimental Immunology,undefined
[9] NCI-Frederick,undefined
[10] Center for Population Genomics & Pharmacogenetics,undefined
[11] Duke University,undefined
[12] Epidemiology and Biostatistics,undefined
[13] University of California,undefined
[14] Johns Hopkins University,undefined
[15] Bloomberg School of Public Health,undefined
[16] Infections and Immunoepidemiology Branch,undefined
[17] National Cancer Institute,undefined
[18] HIV Research Section,undefined
[19] Johns Hopkins University,undefined
[20] Bloomberg School of Public Health,undefined
[21] Institute of Microbiology,undefined
[22] University of Lausanne,undefined
[23] San Francisco General Hospital,undefined
[24] Ragon Institute of MGH,undefined
[25] MIT and Harvard,undefined
来源：
Nature Genetics | 2009年 / 41卷
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摘要：
Mary Carrington and colleagues follow up on an earlier association of a variant upstream of HLA-C to HIV viral load setpoint, showing that this variant is associated with high HLA-C cell surface expression and demonstrating a protective effect of the variant in viral load and disease progression.
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页码：1290 / 1294
页数：4
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