Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia

被引：0
|
作者：
Annett Spudich
Ertugrul Kilic
Hongyi Xing
Ülkan Kilic
Katharina M Rentsch
Heidi Wunderli-Allenspach
Claudio L Bassetti
Dirk M Hermann
机构：
[1] University Hospital Zurich,Department of Neurology
[2] Frauenklinikstr. 26,Department of Clinical Chemistry
[3] University Hospital Zurich,undefined
[4] Rämistr. 100,undefined
[5] Institute of Pharmaceutical Sciences,undefined
[6] Swiss Federal Institute of Technology,undefined
来源：
Nature Neuroscience | 2006年 / 9卷
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摘要：
The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies.
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页码：487 / 488
页数：1
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