Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia

被引：0
|
作者：
Annett Spudich
Ertugrul Kilic
Hongyi Xing
Ülkan Kilic
Katharina M Rentsch
Heidi Wunderli-Allenspach
Claudio L Bassetti
Dirk M Hermann
机构：
[1] University Hospital Zurich,Department of Neurology
[2] Frauenklinikstr. 26,Department of Clinical Chemistry
[3] University Hospital Zurich,undefined
[4] Rämistr. 100,undefined
[5] Institute of Pharmaceutical Sciences,undefined
[6] Swiss Federal Institute of Technology,undefined
来源：
Nature Neuroscience | 2006年 / 9卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The blood-brain barrier possesses active transporters carrying brain-permeable xenobiotics back into the blood against concentration gradients. We demonstrate that multidrug resistance transporter (Mdr)-1 is upregulated on capillary endothelium after focal cerebral ischemia; moreover, Mdr-1 deactivation by pharmacological inhibition or genetic knockout preferably enhances the accumulation and efficacy of two neuroprotectants known as Mdr-1 substrates in the ischemic brain. We predict that Mdr-1 inhibition may greatly facilitate neuroprotective therapies.
引用
收藏
页码：487 / 488
页数：1
相关论文
共 50 条
  • [1] Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia
    Spudich, A
    Kilic, E
    Xing, HY
    Kilic, Ü
    Rentsch, KM
    Wunderli-Allenspach, H
    Bassetti, CL
    Hermann, DM
    NATURE NEUROSCIENCE, 2006, 9 (04) : 487 - 488
  • [2] Inhibition of multidrug resistance protein-1 (MDR-1) potentiates neuroprotective drug action after focal cerebral ischemia in mice
    Spudich, A.
    Kilic, E.
    Kilic, Ue.
    Wunderli-Allenspach, H.
    Bassetti, C. L.
    Hermann, D. M.
    EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 : 169 - 169
  • [3] Neuroprotection by Rosiglitazone in Transient Focal Cerebral Ischemia Might Not Be Mediated by Glutamate Transporter-1
    Verma, Rajkumar
    Mishra, Vikas
    Gupta, Konica
    Sasmal, Dinakar
    Raghubir, Ram
    JOURNAL OF NEUROSCIENCE RESEARCH, 2011, 89 (11) : 1849 - 1858
  • [4] Polychlorinated biphenyls are not substrates for the multidrug resistance transporter-1
    Tampal, NM
    Robertson, LW
    Srinivasan, C
    Ludewig, G
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2003, 187 (03) : 168 - 177
  • [5] Increased cerebral protein ISGylation after focal ischemia is neuroprotective
    Nakka, Venkata P.
    Lang, Bradley T.
    Lenschow, Deborah J.
    Zhang, Dong-Er
    Dempsey, Robert J.
    Vemuganti, Raghu
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2011, 31 (12): : 2375 - 2384
  • [6] Inhibition of the sodium/hydrogen exchanger is neuroprotective after focal cerebral ischemia: a small animal MRI study
    Ferrazzano, P.
    Shi, A.
    Manhas, N.
    Hutchinson, E.
    Meyerand, E.
    Sun, D.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2009, 29 : S232 - S233
  • [7] Neuroprotective Effect Of Agmatine After Focal Cerebral Ischemia In Diabetic Rats
    Cui, Hui-Song
    Mun, Chin Hee
    Lee, Jong-Eun
    Lee, Won Taek
    Koo, Bon-Nyeo
    Park, Kyung Ah
    STROKE, 2011, 42 (03) : E174 - E174
  • [8] The Neuroprotective Effect of Agmatine After Focal Cerebral Ischemia in Diabetic Rats
    Cui, Huisong
    Lee, Jae Hoon
    Kim, Ji Young
    Koo, Bon-Nyeo
    Lee, Jong Eun
    JOURNAL OF NEUROSURGICAL ANESTHESIOLOGY, 2012, 24 (01) : 39 - 50
  • [9] The neuroprotective effects of R-phenibut after focal cerebral ischemia
    Vavers, Edijs
    Zvejniece, Liga
    Svalbe, Baiba
    Volska, Kristine
    Makarova, Elina
    Liepinsh, Edgars
    Rizhanova, Kristina
    Liepins, Vilnis
    Dambrova, Maija
    PHARMACOLOGICAL RESEARCH, 2016, 113 : 796 - 801
  • [10] Inhibition of glial glutamate transporter GLT-1 augments brain edema after transient focal cerebral ischemia in mice
    Namura, S
    Maeno, H
    Takami, S
    Jiang, XF
    Kamichi, S
    Wada, K
    Nagata, I
    NEUROSCIENCE LETTERS, 2002, 324 (02) : 117 - 120
12345