COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection

被引：0
作者：
Stephany Beyerstedt
Expedito Barbosa Casaro
Érika Bevilaqua Rangel
机构：
[1] Hospital Israelita Albert Einstein,Albert Einstein Research and Education Institute
[2] Federal University of São Paulo,Nephrology Division
来源：
European Journal of Clinical Microbiology & Infectious Diseases | 2021年 / 40卷
关键词：
Angiotensin-converting enzyme; COVID-19; SARS-CoV-2; Tissue damage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
COVID-19 pandemic is caused by the novel coronavirus SARS-CoV-2. Angiotensin-converting enzyme 2 (ACE2) is not only an enzyme but also a functional receptor on cell surfaces through which SARS-CoV-2 enters the host cells and is highly expressed in the heart, kidneys, and lungs and shed into the plasma. ACE2 is a key regulator of the renin–angiotensin–aldosterone system (RAAS). SARS-CoV-2 causes ACE/ACE2 balance disruption and RAAS activation, which leads ultimately to COVID-19 progression, especially in patients with comorbidities, such as hypertension, diabetes mellitus, and cardiovascular disease. Therefore, ACE2 expression may have paradoxical effects, aiding SARS-CoV-2 pathogenicity, yet conversely limiting viral infection. This article reviews the existing literature and knowledge of ACE2 in COVID-19 setting and focuses on its pathophysiologic involvement in disease progression, clinical outcomes, and therapeutic potential.
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页码：905 / 919
页数：14
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