Is there a predictive significance of ABO blood group on chemotherapy-induced thrombocytopenia in patients with stage III colon cancer?

被引：0
作者：
Ozgur Tanriverdi
机构：
[1] Mugla Sitki Kocman University,Department of Medical Oncology, Faculty of Medicine
[2] Mugla Universitesi Egitim ve Arastirma Hastanesi,undefined
[3] Onkoloji Bolumu,undefined
来源：
Medical Oncology | 2015年 / 32卷
关键词：
Blood group; Thrombocytopenia; Colon cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Chemotherapy-induced thrombocytopenia (CIT) is the most important cause of thrombocytopenia in cancer patients. In this paper, I discussed the effect of ABO blood group on CIT in patients with stage III colon cancer. In a pilot study, a total of 131 (72 men, 55 %) eligible patients with stage III colon cancer were divided into two groups according to whether they had CIT. Both groups were compared using demographic, histopathological, and laboratory variables. CIT was detected in 51 (40 %) of 131 patients. The incidence of CIT had a significant increased in patients with 0 blood group compared to other blood groups. It was concluded that the relationship between blood group 0 and the presence of CIT in patients with stage III colon cancer is independent of other study variables (P = 0.035, OR 3.14, 95 % CI 1.16–7.01). In conclusion, I hypothesized that 0 blood group may predict to differentiate high-risk patients for CIT.
引用
收藏
相关论文
共 86 条
[1]  
ten Berg MJ(2011)Thrombocytopenia in adult cancer patients receiving cytotoxic chemotherapy: results from a retrospective hospital-based cohort study Drug Saf 34 1151-1160
[2]  
van den Bemt PM(2006)Chemotherapy-associated thrombocytopenia: current and emerging management strategies Am J Cancer 6 372-382
[3]  
Shantakumar S(2011)Incidence and risk factors of clinically significant chemotherapy-induced thrombocytopenia in patients with solid tumors J Oncol Pharm Pract 17 312-319
[4]  
Bennett D(2010)Dose escalation study of an anti-thrombocytopenic agent in patients with chemotherapy-induced thrombocytopenia BMC Cancer 10 565-572
[5]  
Voest EE(2011)Prevention of chemotherapy-induced anemia and thrombocytopenia by constant administration of stem cell factor Clin Cancer Res 17 6185-6191
[6]  
Jelic S(2011)A rational approach to the diagnosis and management of thrombocytopenia in the hospitalized patient Semin Hematol 48 251-258
[7]  
Radulovic S(2006)Thrombocytopenia in adults: a practical approach to evaluation and management South Med J 99 491-498
[8]  
Hitron A(2012)Multicenter, randomized study of genetically modified recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in cancer patients receiving chemotherapy Support Care Cancer 20 1875-1884
[9]  
Steinke D(2013)Association of Platelets 23 1805-1810
[10]  
Sutphin S(2012) infection with chemotherapy-induced thrombocytopenia in patients with stage III colon cancer: a pilot study Cancer Causes Control 20 1017-1020
123456789