Effect of cardiopulmonary bypass on beta adrenergic receptor-adenylate cyclase system on surfaces of peripheral lymphocytes

被引：0

作者：

Luo Ailin

Tian Yuke

Jin Shiao

机构：

[1] Tongji Medical University,Department of Anesthesiology, Tongji Hospital

来源：

Current Medical Science | 2000年 / 20卷 / 1期

关键词：

cardiopulmonary bypass; adrenergic beta receptor-adenylate cyclase; cellular immunity;

D O I：

10.1007/BF02887684

中图分类号：

学科分类号：

摘要：

The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP, IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after cardiopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces, which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.

引用

页码：77 / 78

页数：1

共 14 条

[1]

Carey G B(1995)Stimulation of receptor-associated kinase, tyrosine kinase, and MAP Kinase is required for prolactin-mediated macromolecular biosynthesis and mitogenesis in NB2 lymphoma Arch Biochem Biophys 316 179-179

[2]

Liberti J P(1995)Influence of polyunsaturated fatty acids on lipid metabolism in human blood mononuclear cells and early biochemical events associated with lymphocyte activation J Lipid Mediat Cell Signal 11 63-63

[3]

Joulain C(1994)Priming effects of granulocyte-macrophage colony-stimulating factor are coupled to cholera toxin-sensitive guanine nucleotide binding protein in human T lymphocytes Blood 83 1299-1299

[4]

Guichardant M(1993)Modulation of rat thymocyte proliferative response through the inhibition of different cyclic nucleotide phosphodiesterase isoforms by means of selective inhibitors and cGMP-elevating agents Mol Pharmacol 44 1027-1027

[5]

Lagarde M(1990)Effects of canine endotoxin shock on lymphocyte beta-adrenergic receptors Circ Shock 32 293-293

[6]

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