T-Cell Prolymphocytic Leukemia With Hemorrhagic Gastrointestinal Involvement and a New Chromosomal Abnormality

被引：0
作者：
Shigeo Toyota
Norihiko Nakamura
Kazuo Dan
机构：
[1] Yokosuka Kyousai Hospital,Department of Internal Medicine
[2] Nippon Medical School,Third Department of Internal Medicine
[3] Yokosuka Kyousai Hospital,Department of Internal Medicine
来源：
International Journal of Hematology | 2002年 / 75卷
关键词：
T-cell prolymphocytic leukemia; Chromosomal abnormality; Gastrointestinal involvement;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We report a case of T-cell prolymphocytic leukemia in a 56-year-old woman who exhibited hemorrhaging with gastric involvement as the first manifestation. This patient’s condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy, and cutaneous involvement. Endoscopic examination of the upper gastrointestinal tract revealed hemorrhage from a gastric lesion with histological involvement. Cytogenetic analysis revealed chromosomal abnormalities, 46,XX,der(1),add(1)(p36), that have not previously been described in T-cell prolymphocytic leukemia. In spite of a transient response to chemotherapy, the patient died 15 months after onset of the disease.
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页码：314 / 317
页数：3
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