Gene-specific RNA polymerase II phosphorylation and the CTD code

被引：0
作者：
Hyunmin Kim
Benjamin Erickson
Weifei Luo
David Seward
Joel H Graber
David D Pollock
Paul C Megee
David L Bentley
机构：
[1] University of Colorado School of Medicine,Department of Biochemistry and Molecular Genetics
[2] The Jackson Laboratory,undefined
[3] Current address: Department of Biology,undefined
[4] Howard Hughes Medical Institute,undefined
[5] Brandeis University,undefined
[6] Waltham,undefined
[7] Massachusetts,undefined
[8] USA.,undefined
来源：
Nature Structural & Molecular Biology | 2010年 / 17卷
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摘要：
The C-terminal domain (CTD) of RNA polymerase II (Pol II) contains a number of repeats, phosphorylation of which influences RNA processing factor recruitment. Genome-wide CTD phosphorylation is now assessed and found not to be scaled to gene length. The kinases mediating these modifications are found not to alter Pol II distribution across a given gene uniformly, arguing that CTD phosphorylation is gene specific.
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页码：1279 / 1286
页数：7
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