Effect of Unsymmetrical Dimethylhydrazine on Isolated Heart and Lymphatic Vessels

被引：0

作者：

O. V. Nechaykina

D. S. Laptev

S. G. Petunov

D. V. Bobkov

机构：

[1] Research Institute of Hygiene,

[2] Occupational Pathology and Human Ecology,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2022年 / 172卷

关键词：

isolated heart; isolated lymphatic vessels; unsymmetrical dimethylhydrazine; (UDMH); toxicological research;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Unsymmetrical dimethylhydrazine (UDMH, heptyl) and its derivatives are used in the rocket and space industry as components of rocket fuel. UDMH is a highly toxic compound exhibiting irritant, hepatotoxic, and neurotoxic properties. In this study, the toxic effect of heptyl on isolated rat heart and lymphatic vessels was demonstrated. Acute exposure to UDMH leads to vasoconstriction of the coronary vessels of the isolated heart and pronounced stimulation of isolated lymphangions starting from the concentration of 10-4 M. The changes are dose-dependent. After exposure to UDMH in high concentrations (10-2 M), the changes in the functional parameters became irreversible. The obtained results provide evidence for the organ-specific effect of UDMH on visceral muscle organs.

引用

页码：297 / 300

页数：3

共 4 条

[1] Avakyan AK(1990)New molecular criteria for evaluating the toxic effect of hydrazine derivatives. Reactive oxygen species as key agents in the toxicity mechanism Farmakol. Toksikol. 53 70-73
[2] Belov AA(2000)On the toxicity and hazard of hydrazine and its derivatives Sovremen. Probl. Toksikol. 1 25-32
[3] Lavrinenko IA(2012)1,1-Dimethylhydrazine: mutagenic and general toxic properties Vestn. Novosib. Gos. Univer. Ser.: Biol., Klin. Med. 10 229-236
[4] Lavrinenko VA(undefined)undefined undefined undefined undefined-undefined

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