Immunomodulation as innovative therapy for head and neck tumors. Current developments

被引：1
|
作者：
Schuler, P. J. [1 ]
Doescher, J. C. [1 ]
Laban, S. [1 ]
Hoffmann, T. K. [1 ]
机构：
[1] Univ Ulm Klinikum, Univ Klin Hals Nasen Ohrenheilkunde Kopf & Halsch, Frauensteige 12, D-89075 Ulm, Germany
来源：
HNO | 2016年 / 64卷 / 07期
关键词：
Head and neck neoplasms; Immunotherapy; Monoclonal antibodies; Programmed cell death 1 receptor; Vaccination; SQUAMOUS-CELL CARCINOMA; RECEPTOR FUSION PROTEIN; PHASE-I TRIAL; OPEN-LABEL; CANCER; RECURRENT; IMMUNOTHERAPY; DALANTERCEPT; COMBINATION; VACCINATION;
D O I：
10.1007/s00106-016-0131-0
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Head and neck squamous cell carcinoma (HNSCC) is characterized by its intense immune suppression and its elaborate immune escape mechanisms. Due to the fact that survival rates remain low, the role of immunotherapy has become more important and the focus of current clinical studies has shifted toward antibody-based immune checkpoint modulation. Application of immunotherapy in curative settings or for prevention of recurrent disease would be desirable.
引用
收藏
页码：470 / 478
页数：9
相关论文
共 50 条
  • [41] Recurrent squamous-cell carcinoma of the head and neck: Overview of current therapy and future prospects
    Ganly, I
    Kaye, SB
    ANNALS OF ONCOLOGY, 2000, 11 (01) : 11 - 16
  • [42] Standard Therapy of receded/metastized and locally advanced Head-Neck-Tumors
    Stumpf, Holger
    ONKOLOGIE, 2011, 34 (8-9): : 476 - 477
  • [43] Palliative Quad Shot Radiation Therapy with or without Concurrent Immune Checkpoint Inhibition for Head and Neck Cancer
    Upadhyay, Rituraj
    Gogineni, Emile
    Tocaj, Glenis
    Ma, Sung J.
    Bonomi, Marcelo
    Bhateja, Priyanka
    Konieczkowski, David J.
    Baliga, Sujith
    Mitchell, Darrion L.
    Jhawar, Sachin R.
    Zhu, Simeng
    Grecula, John C.
    Dibs, Khaled
    Gamez, Mauricio E.
    Blakaj, Dukagjin M.
    CANCERS, 2024, 16 (05)
  • [44] HPV status in head and neck tumors
    Glombitza, Felix
    Guntinas-Lichius, Orlando
    Petersen, Iver
    PATHOLOGY RESEARCH AND PRACTICE, 2010, 206 (04) : 229 - 234
  • [45] Radiotherapy of rare head and neck tumors
    Sauvage, L.
    Calugaru, V.
    Janoray, G.
    CANCER RADIOTHERAPIE, 2023, 27 (6-7): : 608 - 613
  • [46] Induction chemotherapy in head and neck tumors
    Dietz, A.
    Boehm, A.
    Niederwieser, D.
    ONKOLOGE, 2010, 16 (11): : 1099 - 1104
  • [47] Current status and perspective of tumor immunotherapy for head and neck squamous cell carcinoma
    Yu, Chenhang
    Li, Qiang
    Zhang, Yu
    Wen, Zhi-Fa
    Dong, Heng
    Mou, Yongbin
    FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 10
  • [48] Head and neck cancer: pathogenesis and targeted therapy
    Liu, Yan
    Zhang, Nannan
    Wen, Yi
    Wen, Jiaolin
    MEDCOMM, 2024, 5 (09):
  • [49] CURRENT PERSPECTIVES IN THE USE OF MONOCLONAL-ANTIBODIES FOR DETECTION AND TREATMENT OF HEAD AND NECK TUMORS
    QUAK, J
    VANDONGEN, G
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 1994, 251 (01) : 1 - 5
  • [50] Current status of head and neck cancer therapy in the elderly
    Sesterhenn, A. M.
    LARYNGO-RHINO-OTOLOGIE, 2007, 86 (02) : 95 - 100
12345