14-3-3σ controls mitotic translation to facilitate cytokinesis

被引：0
|
作者：
Erik W. Wilker
Marcel A. T. M. van Vugt
Stephen C. Artim
Paul H. Huang
Christian P. Petersen
H. Christian Reinhardt
Yun Feng
Phillip A. Sharp
Nahum Sonenberg
Forest M. White
Michael B. Yaffe
机构：
[1] Center for Cancer Research,Department of Biology and
[2] Biological Engineering,Department of Biochemistry
[3] Massachusetts Institute of Technology,undefined
[4] Cambridge,undefined
[5] Massachusetts 02139,undefined
[6] USA,undefined
[7] McGill Cancer Centre,undefined
[8] McGill University,undefined
[9] Montreal,undefined
[10] Quebec,undefined
[11] H3G 1Y6,undefined
[12] Canada,undefined
来源：
Nature | 2007年 / 446卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The protein known as 14-3-3σ is an important p53-regulated human tumour suppressor that is lost early in cancer development. A possible molecular basis for its function has now been found. While mRNA translation normally switches from a 'cap-dependent' to 'cap-independent' mechanism during mitosis, cells lacking 14-3-3σ don't make this switch, and consequently have cell division abnormalities.
引用
收藏
页码：329 / 332
页数：3
相关论文
共 50 条
  • [41] The 14-3-3 cancer connection
    Hermeking, H
    NATURE REVIEWS CANCER, 2003, 3 (12) : 931 - 943
  • [42] 14-3-3 proteins in apoptosis
    Rosenquist, M
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2003, 36 (04) : 403 - 408
  • [43] Yeast 14-3-3 proteins
    van Heusden, GPH
    Steensma, HY
    YEAST, 2006, 23 (03) : 159 - 171
  • [44] 14-3-3 proteins in neurodegeneration
    Steinacker, Petra
    Aitken, Alastair
    Otto, Markus
    SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (07) : 696 - 704
  • [45] α- and β-synuclein interactions with 14-3-3
    Falconer, H.
    Beck, S.
    Houston, N.
    Vigbedor, M.
    Maltas, E.
    Aitken, A.
    JOURNAL OF NEUROCHEMISTRY, 2010, 113 : 8 - 8
  • [46] 14-3-3 proteins—an update
    Paulette MHAWECH
    Cell Research, 2005, (04) : 228 - 236
  • [47] Crystallization of a 14-3-3 protein
    Xiao, B
    Jones, D
    Madrazo, J
    Soneji, Y
    Aitken, A
    Gamblin, S
    ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1996, 52 : 203 - 206
  • [48] 14-3-3 proteins - an update
    Mhawech, P
    CELL RESEARCH, 2005, 15 (04) : 228 - 236
  • [49] 14-3-3 PROTEINS ON THE MAP
    AITKEN, A
    TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) : 95 - 97
  • [50] 14-3-3σ controls keratinocyte proliferation/differentiation switch and responsiveness to IGF-1
    Cianfarani, Francesca
    De Luca, Naomi
    Dellambra, Elena
    Tatangelo, Laura
    Tiveron, Cecilia
    Niessen, Carien M.
    Zambruno, Giovanna
    Castiglia, Daniele
    Odorisio, Teresa
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 : S52 - S52
12345