14-3-3σ controls mitotic translation to facilitate cytokinesis

被引：0
|
作者：
Erik W. Wilker
Marcel A. T. M. van Vugt
Stephen C. Artim
Paul H. Huang
Christian P. Petersen
H. Christian Reinhardt
Yun Feng
Phillip A. Sharp
Nahum Sonenberg
Forest M. White
Michael B. Yaffe
机构：
[1] Center for Cancer Research,Department of Biology and
[2] Biological Engineering,Department of Biochemistry
[3] Massachusetts Institute of Technology,undefined
[4] Cambridge,undefined
[5] Massachusetts 02139,undefined
[6] USA,undefined
[7] McGill Cancer Centre,undefined
[8] McGill University,undefined
[9] Montreal,undefined
[10] Quebec,undefined
[11] H3G 1Y6,undefined
[12] Canada,undefined
来源：
Nature | 2007年 / 446卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The protein known as 14-3-3σ is an important p53-regulated human tumour suppressor that is lost early in cancer development. A possible molecular basis for its function has now been found. While mRNA translation normally switches from a 'cap-dependent' to 'cap-independent' mechanism during mitosis, cells lacking 14-3-3σ don't make this switch, and consequently have cell division abnormalities.
引用
收藏
页码：329 / 332
页数：3
相关论文
共 50 条
  • [31] 14-3-3 α and 14-3-3 ξ contribute to immune responses in planarian Dugesia japonica
    Lu, Qingqing
    Wu, Suge
    Zhen, Hui
    Deng, Hongkuan
    Song, Qian
    Ma, Kaifu
    Cao, Zhonghong
    Pang, Qiuxiang
    Zhao, Bosheng
    GENE, 2017, 615 : 25 - 34
  • [32] 14-3-3 β, but not 14-3-3 γ, Supports Nuclear Transport of Synaptopodin 2 (Myopodin).
    Ardestani, M. Abootorabi
    Linde, N. F.
    Papadopoulos, S.
    Pfitzer, G.
    Schroeter, M.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [33] Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation
    Czirjak, Gabor
    Vuity, Drazsen
    Enyedi, Peter
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (23) : 15672 - 15680
  • [34] Inhibition of 14-3-3 binding to keratins alters mitotic progression and protects from hepatotoxic injury
    Ku, NO
    Resurreccion, EZ
    Broome, RL
    Michie, SA
    Omary, MB
    GASTROENTEROLOGY, 2001, 120 (05) : A28 - A28
  • [35] 14-3-3ζ与肿瘤
    曾琴
    科技视界, 2017, (19) : 152 - 153
  • [36] The 14-3-3 cancer connection
    Heiko Hermeking
    Nature Reviews Cancer, 2003, 3 : 931 - 943
  • [37] 14-3-3 proteins—an update
    Paulette MHAWECH
    Cell Research, 2005, 15 : 228 - 236
  • [38] Yeast 14-3-3 proteins
    van Hemert, MJ
    van Heusden, GPH
    Steensma, HY
    YEAST, 2001, 18 (10) : 889 - 895
  • [39] Normalization of 14-3-3 in CJD
    Schrooten, Maarten
    De Vooght, Wouter
    Weckhuysen, Sarah
    Van Paesschen, Wirn
    Van Damme, Philip
    ACTA NEUROLOGICA BELGICA, 2008, 108 (02) : 64 - 66
  • [40] Unlocking the code of 14-3-3
    Dougherty, MK
    Morrison, DK
    JOURNAL OF CELL SCIENCE, 2004, 117 (10) : 1875 - 1884
12345