14-3-3σ controls mitotic translation to facilitate cytokinesis

被引：0
|
作者：
Erik W. Wilker
Marcel A. T. M. van Vugt
Stephen C. Artim
Paul H. Huang
Christian P. Petersen
H. Christian Reinhardt
Yun Feng
Phillip A. Sharp
Nahum Sonenberg
Forest M. White
Michael B. Yaffe
机构：
[1] Center for Cancer Research,Department of Biology and
[2] Biological Engineering,Department of Biochemistry
[3] Massachusetts Institute of Technology,undefined
[4] Cambridge,undefined
[5] Massachusetts 02139,undefined
[6] USA,undefined
[7] McGill Cancer Centre,undefined
[8] McGill University,undefined
[9] Montreal,undefined
[10] Quebec,undefined
[11] H3G 1Y6,undefined
[12] Canada,undefined
来源：
Nature | 2007年 / 446卷
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学科分类号：
摘要：
The protein known as 14-3-3σ is an important p53-regulated human tumour suppressor that is lost early in cancer development. A possible molecular basis for its function has now been found. While mRNA translation normally switches from a 'cap-dependent' to 'cap-independent' mechanism during mitosis, cells lacking 14-3-3σ don't make this switch, and consequently have cell division abnormalities.
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页码：329 / 332
页数：3
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