Extracellular signal-regulated kinase 1 and 2 in cancer therapy: a focus on hepatocellular carcinoma

被引：0
作者：
Amir Mehdizadeh
Mohammad Hossein Somi
Masoud Darabi
Mortaza Jabbarpour-Bonyadi
机构：
[1] Tabriz University of Medical Sciences,Liver and Gastrointestinal Diseases Research Center
[2] Tabriz University of Medical Sciences,Stem Cell Research Center
[3] University of Tabriz,Center of Excellence for Biodiversity, Faculty of Natural Sciences
来源：
Molecular Biology Reports | 2016年 / 43卷
关键词：
Hepatocellular carcinoma; ERK; Chemoresistance;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Extracellular signal-regulated kinases (ERK) pathway plays a crucial role in cancer cell survival and proliferation. This signaling pathway has been related to epithelial to mesenchymal transition and drug resistance in hepatocellular carcinoma (HCC) cells, which is a common challenge in chemotherapy. Consequently, mediators of this pathway have recently been considered as novel therapeutic targets in HCC. In this review the impact of ERK1 and ERK2 as major components of ERK signaling pathway, in HCC biology and drug resistance will be highlighted and discussed.
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页码：107 / 116
页数：9
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