Cardiac contractility modulation therapy in advanced systolic heart failure

被引：0
作者：
Alexander R. Lyon
Michael A. Samara
David S. Feldman
机构：
[1] NIHR Cardiovascular Biomedical Research Unit,
[2] Royal Brompton Hospital,undefined
[3] Minneapolis Heart Institute,undefined
[4] Abbott Northwestern Hospital,undefined
[5] Georgia Insitute of Technology,undefined
[6] Morehouse School of Medicine,undefined
来源：
Nature Reviews Cardiology | 2013年 / 10卷
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学科分类号：
摘要：
Cardiac contractility modulation has positive inotropic effects in the failing heart, without increasing oxygen consumption. Here, Lyon and colleagues review the preclinical data, mode of action, and clinical evidence for the use of this therapy in patients with chronic heart failure. Long-term application of cardiac contractility modulation seems to improve exercise tolerance and quality of life, and have an acceptable safety profile.
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页码：584 / 598
页数：14
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[1]  
Swedberg K(2010)Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study Lancet 376 875-885
[2]  
Wood EH(1969)Inotropic effects of electric currents Circ. Res. 24 409-445
[3]  
Heppner RL(2009)Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy Circulation 119 1220-1230
[4]  
Weidmann S(2006)Left ventricular assist device and drug therapy for the reversal of heart failure N. Engl. J. Med. 355 1873-1884
[5]  
Aiba T(2008)Reversal of cardiac dysfunction after long-yerm expression of SERCA2a by gene transfer in a pre-clinical model of heart failure J. Am. Coll. Cardiol. 51 1112-1119
[6]  
Birks EJ(2004)Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy Circulation 109 2263-2265
[7]  
Kawase Y(1999)Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST) Am. Heart J. 138 78-86
[8]  
Terracciano CMN(1991)Effect of oral milrinone on mortality in severe chronic heart failure N. Engl. J. Med. 325 1468-1475
[9]  
O'Connor CM(2001)Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure Circulation 104 1424-1429
[10]  
Packer M(2005)Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis Cardiovasc. Toxicol. 5 355-364
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