Bioorthogonal Chemistry in Cellular Organelles

被引：0
作者：
Veronika Šlachtová
Marek Chovanec
Michal Rahm
Milan Vrabel
机构：
[1] Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences,Department of Bioorganic and Medicinal Chemistry
[2] University of Chemistry and Technology,undefined
来源：
Topics in Current Chemistry | 2024年 / 382卷
关键词：
Bioorthogonal reactions; Bioconjugations; Cellular organelles; Click chemistry; Targeting;
D O I：
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中图分类号：
学科分类号：
摘要：
While bioorthogonal reactions are routinely employed in living cells and organisms, their application within individual organelles remains limited. In this review, we highlight diverse examples of bioorthogonal reactions used to investigate the roles of biomolecules and biological processes as well as advanced imaging techniques within cellular organelles. These innovations hold great promise for therapeutic interventions in personalized medicine and precision therapies. We also address existing challenges related to the selectivity and trafficking of subcellular dynamics. Organelle-targeted bioorthogonal reactions have the potential to significantly advance our understanding of cellular organization and function, provide new pathways for basic research and clinical applications, and shape the direction of cell biology and medical research.
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