Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase

被引:0
作者
Ayako Nakamura
Go Nakajima
Ryuji Okuyama
Hidekazu Kuramochi
Yurin Kondoh
Toshinori Kanemura
Teiji Takechi
Masakazu Yamamoto
Kazuhiko Hayashi
机构
[1] Tokyo Women’s Medical University Graduate School of Medicine,Field of Chemotherapy on Digestive Organs Division of Gastrointestinal Surgery
[2] Tokyo Women’s Medical University,Department of Chemotherapy and Palliative Care
[3] Taiho Pharmaceutical Co.,Oncology Medical Affairs Department
[4] Ltd,Department of Surgery, Institute of Gastroenterology
[5] Tokyo Women’s Medical University,Laboratory for Oncology Medication Management and Development
[6] Taiho Pharmaceutical Co.,undefined
[7] Ltd,undefined
来源
Gastric Cancer | 2014年 / 17卷
关键词
Gastric cancer; 5-Fluorouracil; Leucovorin; Acquired resistance; Thymidylate synthase;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:188 / 195
页数:7
相关论文
共 187 条
[1]  
Jemal A(2011)Global cancer statistics CA Cancer J Clin 61 69-90
[2]  
Bray F(1974)Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides Biochemistry 13 926-933
[3]  
Center MM(2008)Chemotherapy for metastatic disease: review from JCOG trials Int J Clin Oncol 13 196-200
[4]  
Ferlay J(2007)Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine N Engl J Med 357 1810-1820
[5]  
Ward E(2010)Benefit of adjuvant chemotherapy for resectable gastric cancer: a meta-analysis JAMA 303 1729-37
[6]  
Forman D(1974)Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate Biochemistry 13 471-481
[7]  
Danenberg PV(1994)A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil Eur J Cancer 30A 1517-1522
[8]  
Langenbach RJ(1996)Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival J Clin Oncol 14 176-182
[9]  
Heidelberger C(2004)Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer Br J Cancer 91 1245-1250
[10]  
Boku N(2000)Dihydropyrimidine dehydrogenase and messenger RNA levels in gastric cancer: possible predictor for sensitivity to 5-fluorouracil Jpn J Cancer Res 91 105-112