Reproductive risks in 35-year-old adults born very preterm and/or with very low birth weight: an observational study

被引:0
作者
Sylvia M. van der Pal
Sanne A. van der Meulen
Sophie M. Welters
Leonhard A. Bakker
Christianne J. M. de Groot
Anton H. van Kaam
Erik (G.H.W.) Verrips
机构
[1] TNO Child Health,Department of Obstetrics and Gynecology, Amsterdam UMC, Vrije Universiteit Amsterdam
[2] Amsterdam Reproduction & Development Research Institute,Department of Neonatology, Emma Children’s Hospital, Amsterdam UMC
[3] University of Amsterdam,undefined
来源
European Journal of Pediatrics | 2021年 / 180卷
关键词
Reproduction; Very preterm; Very low birth weight; Preterm-born adults;
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摘要
Evidence suggests that increased survival over the last decades of very preterm (VPT; gestational age < 32 weeks)– and very low birth weight (VLBW; birth weight < 1500 g)–born infants is not matched by improved outcomes. The objective of our study was to evaluate the reproductive rate, fertility, and pregnancy complications in 35-year-old VPT/VLBW subjects. All Dutch VPT/VLBW infants born alive in 1983 and surviving until age 35 (n = 955) were eligible for a POPS-35 study. A total of 370 (39%) subjects completed a survey on reproductive rate, fertility problems, pregnancy complications, and perinatal outcomes of their offspring. We tested differences in these parameters between the VPT/VLBW subjects and their peers from Dutch national registries. POPS-35 participants had less children than their peers in the CBS registry. They reported more problems in conception and pregnancy complications, including a three times increased risk of hypertension during pregnancy.
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页码:1219 / 1228
页数:9
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