Reproductive risks in 35-year-old adults born very preterm and/or with very low birth weight: an observational study

被引：0
作者：
Sylvia M. van der Pal
Sanne A. van der Meulen
Sophie M. Welters
Leonhard A. Bakker
Christianne J. M. de Groot
Anton H. van Kaam
Erik (G.H.W.) Verrips
机构：
[1] TNO Child Health,Department of Obstetrics and Gynecology, Amsterdam UMC, Vrije Universiteit Amsterdam
[2] Amsterdam Reproduction & Development Research Institute,Department of Neonatology, Emma Children’s Hospital, Amsterdam UMC
[3] University of Amsterdam,undefined
来源：
European Journal of Pediatrics | 2021年 / 180卷
关键词：
Reproduction; Very preterm; Very low birth weight; Preterm-born adults;
D O I：
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摘要：
Evidence suggests that increased survival over the last decades of very preterm (VPT; gestational age < 32 weeks)– and very low birth weight (VLBW; birth weight < 1500 g)–born infants is not matched by improved outcomes. The objective of our study was to evaluate the reproductive rate, fertility, and pregnancy complications in 35-year-old VPT/VLBW subjects. All Dutch VPT/VLBW infants born alive in 1983 and surviving until age 35 (n = 955) were eligible for a POPS-35 study. A total of 370 (39%) subjects completed a survey on reproductive rate, fertility problems, pregnancy complications, and perinatal outcomes of their offspring. We tested differences in these parameters between the VPT/VLBW subjects and their peers from Dutch national registries. POPS-35 participants had less children than their peers in the CBS registry. They reported more problems in conception and pregnancy complications, including a three times increased risk of hypertension during pregnancy.
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页码：1219 / 1228
页数：9
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