Dose-response associations of triglyceride to high-density lipoprotein cholesterol ratio and triglyceride-glucose index with arterial stiffness risk

被引：3

作者：

Zhang, Wenkai ^{[1
]}

Huo, Weifeng ^{[1
]}

Hu, Huifang ^{[1
]}

Li, Tianze ^{[1
]}

Yuan, Lijun ^{[1
]}

Zhang, Jinli ^{[1
]}

Feng, Yifei ^{[1
]}

Wu, Yuying ^{[1
]}

Fu, Xueru ^{[1
]}

Ke, Yamin ^{[1
]}

Wang, Mengmeng ^{[1
]}

Wang, Longkang ^{[1
]}

Chen, Yaobing ^{[1
]}

Gao, Yajuan ^{[1
]}

Li, Xi ^{[1
]}

Sun, Liang ^{[2
]}

Pang, Jinyuan ^{[3
]}

Zheng, Zeqiang ^{[3
]}

Hu, Fulan ^{[4
,5
]}

Zhang, Ming ^{[4
,5
]}

Liu, Yu ^{[6
]}

Hu, Dongsheng ^{[1
,7
]}

Zhao, Yang ^{[1
,7
]}

机构：

[1] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Hlth Stat, Zhengzhou, Henan, Peoples R China

[2] Zhengzhou Univ, Coll Publ Hlth, Dept Social Med & Hlth Management, Zhengzhou 450001, Henan, Peoples R China

[3] Shenzhen Univ, Sch Publ Hlth, Dept Prevent Med, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China

[4] Shenzhen Univ, Sch Publ Hlth, Hlth Sci Ctr, Dept Biostat & Epidemiol, Shenzhen, Guangdong, Peoples R China

[5] Shenzhen Univ, Guangdong Prov Key Lab Reg Immun & Dis, Hlth Sci Ctr, Shenzhen, Guangdong, Peoples R China

[6] Shenzhen Univ, Affiliated Luohu Hosp, Hlth Sci Ctr, Dept Gen Practice, Shenzhen, Guangdong, Peoples R China

[7] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol & Biostat, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China

来源：

LIPIDS IN HEALTH AND DISEASE | 2024年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Triglyceride to high-density lipoprotein cholesterol ratio; Triglyceride-glucose index; Arterial stiffness; Pulse wave velocity; Meta-analysis; EXPERT CONSENSUS DOCUMENT; EPITHELIAL SODIUM-CHANNEL; PULSE-WAVE VELOCITY; INSULIN-RESISTANCE; CARDIOVASCULAR EVENTS; MORTALITY; HYPERGLYCEMIA; METAANALYSIS;

D O I：

10.1186/s12944-024-02095-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are novel indexes for insulin resistance (IR). We aimed to evaluate associations of TG/HDL-C and TyG with arterial stiffness risk.Methods We enrolled 1979 participants from the Rural Chinese Cohort Study, examining arterial stiffness by brachial-ankle pulse wave velocity (baPWV). Logistic and linear regression models were employed to calculate effect estimates. For meta-analysis, we searched relevant articles from PubMed, Embase and Web of Science up to August 26, 2023. The fixed-effects or random-effects models were used to calculate the pooled estimates. We evaluated dose-response associations using restricted cubic splines.Results For cross-sectional studies, the adjusted ORs (95%CIs) for arterial stiffness were 1.12 (1.01-1.23) and 1.78 (1.38-2.30) for per 1 unit increment in TG/HDL-C and TyG. In the meta-analysis, the pooled ORs (95% CIs) were 1.26 (1.14-1.39) and 1.57 (1.36-1.82) for per 1 unit increment of TG/HDL-C and TyG. Additionally, both TG/HDL-C and TyG were positively related to PWV, with beta of 0.09 (95% CI 0.04-0.14) and 0.57 (95% CI 0.35-0.78) m/s. We also found linear associations of TG/HDL-C and TyG with arterial stiffness risk.Conclusions High TG/HDL-C and TyG were related to increased arterial stiffness risk, indicating TG/HDL-C and TyG may be convincing predictors of arterial stiffness.

引用

页数：11

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