The EUPHRATES trial (Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock): study protocol for a randomized controlled trial

Hotchkiss RS(2003)The pathophysiology and treatment of sepsis N Engl J Med 348 138-150

Karl IE(2001)Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 1303-1310

Angus DC(2011)Novel therapies for septic shock over the past 4 decades JAMA 306 194-199

Linde-Zwirble WT(2010)Improving clinical trials in the critically ill Crit Care Med 38 527-532

Lidicker J(2004)Diagnostic and prognostic mplications of endotoxemia in critical illness: results of the MEDIC study J Infect Dis 190 527-534

Clermont G(1999)Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis? Crit Care Med 27 1608-1616

Carcillo J(2007)Daily variation in endotoxin levels is associated with increased organ failure in critically ill patients Shock 28 524-529

Pinsky MR(2003)Endotoxin as a drug target Crit Care Med 31 S57-S64

Suffredini AF(1982)Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli N Engl J Med 307 1225-1230

Munford RS(1991)A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group JAMA 266 1097-1102

Hotchkiss RS(2003)The pathophysiology and treatment of sepsis N Engl J Med 348 138-150

Karl IE(2001)Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care Crit Care Med 29 1303-1310

Angus DC(2011)Novel therapies for septic shock over the past 4 decades JAMA 306 194-199

Linde-Zwirble WT(2010)Improving clinical trials in the critically ill Crit Care Med 38 527-532

Lidicker J(2004)Diagnostic and prognostic mplications of endotoxemia in critical illness: results of the MEDIC study J Infect Dis 190 527-534

Clermont G(1999)Clinical gram-positive sepsis: does it fundamentally differ from gram-negative bacterial sepsis? Crit Care Med 27 1608-1616

Carcillo J(2007)Daily variation in endotoxin levels is associated with increased organ failure in critically ill patients Shock 28 524-529

Pinsky MR(2003)Endotoxin as a drug target Crit Care Med 31 S57-S64

Suffredini AF(1982)Treatment of gram-negative bacteremia and shock with human antiserum to a mutant Escherichia coli N Engl J Med 307 1225-1230

Munford RS(1991)A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group JAMA 266 1097-1102