Nutrition, bone, and aging: An integrative physiology approach

被引:42
作者
Schulman R.C. [1 ]
Weiss A.J. [1 ]
Mechanick J.I. [1 ]
机构
[1] Division of Endocrinology, Diabetes, and Bone Disease, Mount Sinai School of Medicine, New York, NY 10128
关键词
Aging; Bone remodeling; Integrative physiology; Nutrition; Osteoporosis;
D O I
10.1007/s11914-011-0079-7
中图分类号
学科分类号
摘要
Osteoporosis, a condition associated with significant morbidity and mortality, is prevalent in the growing elderly population. Aging is associated with characteristic changes in the complex pathways of bone remodeling and in patterns of food intake. Whereas the traditional focus of nutritional supplementation for protection of bone health has centered around calcium and vitamin D, a multitude of nutrients have been identified with effects on bone, both individually and in combination. An integrative physiology approach can assist in formulating a deeper understanding of the complex interactions of nutrition and aging with bone, with the goal of identifying modifiable risk factors for the prevention of bone loss. © 2011 Springer Science+Business Media, LLC.
引用
收藏
页码:184 / 195
页数:11
相关论文
共 101 条
  • [1] Palacios C., The role of nutrients in bone health, from A to Z, Critical Reviews in Food Science and Nutrition, 46, 8, pp. 621-628, (2006)
  • [2] Tucker K.L., Osteoporosis prevention and nutrition, Curr Osteoporos Rep, 7, pp. 111-117, (2009)
  • [3] Dennehy C., Tsourounis C., A review of select vitamins and minerals used by postmenopausal women, Maturitas, 66, pp. 370-380, (2010)
  • [4] Body J.J., Bergmann P., Boonen S., Et al., Non-pharmacological management of osteoporosis: A consensus of the Belgian Bone Club, Osteoporos Int., (2011)
  • [5] Weiss A.J., Iqbal J., Zaidi N., Et al., The skeletal subsystem as an integrative physiology paradigm, Curr Osteoporos Rep, 8, pp. 168-177, (2010)
  • [6] Heino T.J., Hentunen T.A., Kalervo Vnnen H., Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-β: Enhancement by estrogen, Journal of Cellular Biochemistry, 85, 1, pp. 185-197, (2002)
  • [7] Raggatt L.J., Partridge N.C., Cellular and molecular mechanisms of bone remodeling, J Biol Chem, 285, pp. 25103-25108, (2010)
  • [8] Nakagawa N., Kinosaki M., Yamaguchi K., Shima N., Yasuda H., Yano K., Morinaga T., Higashio K., RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis, Biochemical and Biophysical Research Communications, 253, 2, pp. 395-400, (1998)
  • [9] Lorenzo J.A., Canalis E., Raisz L.G., Metabolic bone disease, Williams Textbook of Endocrinology, pp. 1269-1310, (2008)
  • [10] Yasuda H., Shima N., Nakagawa N., Yamaguchi K., Kinosaki M., Goto M., Mochizuki S.-I., Tsuda E., Morinaga T., Udagawa N., Takahashi N., Suda T., Higashio K., A novel molecular mechanism modulating osteoclast differentiation and function, Bone, 25, 1, pp. 109-113, (1999)