Early Discontinuation versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients with Febrile Neutropenia, Before Recovery of Counts: A Randomized Controlled Trial (DALFEN Study)

[1] Lucas KG(1996)The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis Cancer. 77 791-798

[2] Brown AE(2002)Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia Clin Infect Dis 35 678-683

[3] Armstrong D(2002)Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer J Pediatr Hematol Oncol 24 38-42

[4] Chapman D(1996)Predicting the risk of bacteremia in childen with fever and neutropenia J Clin Oncol 14 919-924

[5] Heller G(2001)Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever J Clin Oncol 19 3415-3421

[6] Santolaya ME(2010)Predicting adverse events in children with fever and chemotherapy-induced neutropenia: the prospective multicenter SPOG 2003 FN study J Clin Oncol 28 2008-2014

[7] Alvarez AM(1999)A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy N Engl J Med 341 305-311

[8] Aviles CL(2009)Randomized controlled trial comparing oral amoxicillin-clavulanate and ofloxacin with intravenous ceftriaxone and amikacin as outpatient therapy in pediatric low-risk febrile neutropenia J Pediatr Hematol Oncol 31 635-641

[9] Alexander SW(1992)Hematologic predictors of bone marrow recovery in neutropenic patients hospitalized for fever: implications for discontinuation of antibiotics and early discharge from the hospital J Pediatr 121 28-33

[10] Wade KC(2017)Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update J Clin Oncol 35 2082-2094

[1] Lucas KG(1996)The identification of febrile, neutropenic children with neoplastic disease at low risk for bacteremia and complications of sepsis Cancer. 77 791-798

[2] Brown AE(2002)Prospective evaluation of a model of prediction of invasive bacterial infection risk among children with cancer, fever, and neutropenia Clin Infect Dis 35 678-683

[3] Armstrong D(2002)Evaluation of risk prediction criteria for episodes of febrile neutropenia in children with cancer J Pediatr Hematol Oncol 24 38-42

[4] Chapman D(1996)Predicting the risk of bacteremia in childen with fever and neutropenia J Clin Oncol 14 919-924

[5] Heller G(2001)Prospective, multicenter evaluation of risk factors associated with invasive bacterial infection in children with cancer, neutropenia, and fever J Clin Oncol 19 3415-3421

[6] Santolaya ME(2010)Predicting adverse events in children with fever and chemotherapy-induced neutropenia: the prospective multicenter SPOG 2003 FN study J Clin Oncol 28 2008-2014

[7] Alvarez AM(1999)A double-blind comparison of empirical oral and intravenous antibiotic therapy for low-risk febrile patients with neutropenia during cancer chemotherapy N Engl J Med 341 305-311

[8] Aviles CL(2009)Randomized controlled trial comparing oral amoxicillin-clavulanate and ofloxacin with intravenous ceftriaxone and amikacin as outpatient therapy in pediatric low-risk febrile neutropenia J Pediatr Hematol Oncol 31 635-641

[9] Alexander SW(1992)Hematologic predictors of bone marrow recovery in neutropenic patients hospitalized for fever: implications for discontinuation of antibiotics and early discharge from the hospital J Pediatr 121 28-33

[10] Wade KC(2017)Guideline for the management of fever and neutropenia in children with cancer and hematopoietic stem-cell transplantation recipients: 2017 update J Clin Oncol 35 2082-2094