Design and engineering of organ-on-a-chip

被引：0
作者：
Sujin Cho
Sumi Lee
Song Ih Ahn
机构：
[1] Pusan National University,School of Mechanical Engineering
来源：
Biomedical Engineering Letters | 2023年 / 13卷
关键词：
Organ-on-a-chip; Tissue engineering; Microengineering;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Organ-on-a-chip (OOC) is an emerging interdisciplinary technology that reconstitutes the structure, function, and physiology of human tissues as an alternative to conventional preclinical models for drug screening. Over the last decade, substantial progress has been made in mimicking tissue- and organ-level functions on chips through technical advances in biomaterials, stem cell engineering, microengineering, and microfluidic technologies. Structural and engineering constituents, as well as biological components, are critical factors to be considered to reconstitute the tissue function and microenvironment on chips. In this review, we highlight critical engineering technologies for reconstructing the tissue microarchitecture and dynamic spatiotemporal microenvironment in OOCs. We review the technological advances in the field of OOCs for a range of applications, including systemic analysis tools that can be integrated with OOCs, multiorgan-on-chips, and large-scale manufacturing. We then discuss the challenges and future directions for the development of advanced end-user-friendly OOC systems for a wide range of applications.
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页码：97 / 109
页数：12
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[11]  
Korolij A(2017)A low permeability microfluidic blood-brain barrier platform with direct contact between perfusable vascular network and astrocytes Sci Rep undefined undefined-undefined
[12]  
Benjamin FLL(2021)Label-free three-dimensional observations and quantitative characterisation of on-chip vasculogenesis using optical diffraction tomography Lab Chip undefined undefined-undefined
[13]  
Radisic M(2018)Probing the effect of bioinspired nanomaterials on angiogenic sprouting with a microengineered vascular system IEEE Trans Nanotechnol undefined undefined-undefined
[14]  
Ahn SI(2009)Engineering microscale cellular niches for three-dimensional multicellular co-cultures Lab Chip undefined undefined-undefined
[15]  
Shin W(2016)Co-culture of tumor spheroids and fibroblasts in a collagen matrix-incorporated microfluidic chip mimics reciprocal activation in solid tumor microenvironment PLoS ONE undefined undefined-undefined
[16]  
Ingber CD(2021)3D microfluidic platform and tumor vascular mapping for evaluating anti-angiogenic RNAi-based nanomedicine ACS Nano undefined undefined-undefined
[17]  
Kim DE(2020)Endothelial regulation of drug transport in a 3D vascularized tumor model Adv Funct Mater undefined undefined-undefined
[18]  
Jung H(2019)Multiscale reverse engineering of the human ocular surface Nat Med undefined undefined-undefined
[19]  
Si L(2013)Liver-cell patterning lab chip: mimicking the morphology of liver lobule tissue Lab Chip undefined undefined-undefined
[20]  
Bang S(2017)Scaffold-Free Liver-On-A-Chip with Multiscale Organotypic Cultures Adv Mater undefined undefined-undefined
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