A fatal case of acute hepatitis e among pregnant women, Central African Republic

被引：23

作者：

Goumba C.M. ^{[1
]}

Yandoko-Nakouné E.R. ^{[2
]}

Komas N.P. ^{[3
]}

机构：

[1] Service de Gynécologie-Obstétrique, Hpital Communautaire de Bangui

[2] Emerging Diseases Laboratory, Institut Pasteur de Bangui, Bangui, Avenue de l'Indépendance x Rue Louis Pasteur

[3] Viral Hepatitis Laboratory, Institut Pasteur de Bangui, Bangui, Avenue de l'Indépendance x Rue Louis Pasteur

来源：

BMC Research Notes | / 3卷 / 1期

关键词：

Pregnant Woman; Preterm Delivery; Acute Hepatitis; Central African Republic; Live Baby;

D O I：

10.1186/1756-0500-3-103

中图分类号：

学科分类号：

摘要：

Background. Hepatitis E virus (HEV) is a major public health problem in developing countries. HEV infection in pregnant women is more common and more often fatal in the third trimester. The mortality rate due to HEV-induced hepatitis is as high as 15-20 per cent. The present study was designed to determine the potential factors responsible for high mortality rate among pregnant women. Findings. Twenty one pregnant women attended the Maternity Center of Begoua in the Central African Republic during an outbreak of hepatitis E virus between July and October 2002 with symptoms of acute liver disease. Their mean gestational period was 29.9 (SD 8.3 weeks) and they were aged from 15 to 39 years old. The serology IgM showed that seven women (33%) had acute hepatitis E. Among them, one woman, aged 35 and her newborn died after an apparently normal preterm delivery. The 6 remaining young women, age 18 - 22, had preterm deliveries which included three live babies and three stillborn with one macerated. Conclusions. These results suggest that maternal age, in addition to hormonal, immunological and environmental factors, may be a risk factor for fatal outcome. © 2010 Komas et al; licensee BioMed Central Ltd.

引用

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