Efficacy and Tolerability of Conversion from Cyclosporin to Azathioprine After Kidney TransplantationA Review of the Evidence

被引：0
作者：
Adrianus A.M.J. Hollander
Fokko J. van der Woude
机构：
[1] University Hospital,Department of Nephrology and Transplantation
[2] University of Heidelberg,Fifth Medical Clinic, Klinikum Mannheim
[3] Bosch Medicentrum,Department of Internal Medicine and Nephrology
[4] Groot Ziekengasthuis,undefined
来源：
BioDrugs | 1998年 / 9卷
关键词：
Cyclosporin; Adis International Limited; Gout; Acute Rejection; Graft Survival;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
After the introduction of cyclosporin as an immunosuppressive drug for organ transplantation at the beginning of the 1980s, concern arose about adverse effects of this new drug. Nephrotoxicity, fear of progressive loss of renal function with long term use of cyclosporin, a higher incidence of lymphomas in the first studies with cyclosporin and the high costs of the new drug led to the modification of immunosuppressive regimens so that cyclosporin was replaced by azathioprine several months after renal transplantation.
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页码：197 / 210
页数：13
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  • [71] Kerman R.(1995)Important interactions of drugs with immunosuppressive agents used in transplant recipients J An- timicrobial Chemother 36Suppl.B 11-43
  • [72] Flechner S.M.(1993)5’-Nucleotidase and azathioprine-related toxicity Lancet 342 1245-53
  • [73] van Buren C.T.(1989)Cyclosporin: a review of its pharmacodynamic and pharmacokinetic properties, and ther- apeutic use in immunoregulatory disorders Cyclosporin. N Engl J Med 321 1725-53
  • [74] Jarowenko M.(1993)The absorption site of cyclosporin in the human gastrointestinal tract Drugs 45 953-24
  • [75] Flechner S.M.(1992)Pharmacokinetics of cyclosporin in human renal transplantation Br J Clin Pharmacol 33 39-90
  • [76] Lorber M.(1983)Effect of food on the pharmacokinetics of cyclosporin in healthy subjects following oral and intravenous administration Transplant Proc 15 446-32
  • [77] van Buren C.T.(1990)The effect of grapefruit juice on cyclosporin and prednisone metabolism in transplant patients J Clin Pharmacol 30 643-15
  • [78] Canafax D.M.(1995)Cyclosporin metabolism in human liver: identification of a cytochrome P450 III gene family as the major cyclosporin metabolizing enzyme explains interactions of cyclosporin with other drugs Clin Pharmacol Ther 57 318-7
  • [79] Sutherland D.E.R.(1988)First pass metabolism of cyclosporin by the gut Clin Pharmacol Ther 43 6305-20
  • [80] Ascher N.L.(1991)Pharmacokinetic drug interactions with cyclosporin (Part I) Lancet 338 1488-3
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