Hormesis is an evolutionary expectation: implications for aging

被引:0
作者
Edward J. Calabrese
Evgenios Agathokleous
机构
[1] University of Massachusetts,School of Public Health and Health Sciences Department of Environmental Health Sciences, Morrill I, N344
[2] Nanjing University of Information Science and Technology (NUIST),School of Applied Meteorology
来源
Biogerontology | 2022年 / 23卷
关键词
Evolution; Hormesis; Biogerontology; Aging; Mutation; Adaptive response;
D O I
暂无
中图分类号
学科分类号
摘要
This article argues that evolution and the concept of hormesis are biologically inseparable. It proposes that evolutionary processes led to the selection of inducible adaptive hormetic strategies that are necessary for wellbeing and survival. Hormesis has been demonstrated in essentially all organisms in which it has been studied from bacteria to humans, showing its highly conserved features. This evolution-hormesis integration should be a central feature in both understanding the biology of aging but also in ways to enhance improved health-based aging strategies.
引用
收藏
页码:381 / 384
页数:3
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  • [1] Berthelot G(2012)Expediential growth combined with exponential decline explains lifetime performance evolution in individual and human species Age 34 1001-1009
  • [2] Len S(2019)Inflammation as a cancer co-initiator: new mechanistic model predicts low/negligible risk at noninflammatory carcinogen doses Dose Response 17 559325819847834-264
  • [3] Hellard P(2016)Preconditioning is hormesis: part 1. Preconditioning is hormesis: documentation, dose-response features and mechanistic foundations Pharm Res 110 242-275
  • [4] Tafflet M(2016)Preconditioning is hormesis: part 2. How the conditioning dose mediates protection: dose optimization within temporal and mechanistic frameworks Pharm Res 110 265-702
  • [5] Guillaume M(2016)Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration Biogerontology 17 681-204
  • [6] Vollmer JC(2018)The additive to background assumption in cancer risk assessment: a reappraisal Environ Res 166 175-301
  • [7] Gager B(2022)Hormesis and bone marrow stem cells: enhancing cell proliferation, differentiation and resilience to inflammatory stress Chem Biol Interact 351 109730-81
  • [8] Quinquis L(2005)The occurrence of hormetic dose responses in the toxicological literature, the hormesis database: an overview Toxicol Appl Pharm 202 289-329
  • [9] Marc A(2011)The hormesis database: the occurrence of hormetic dose responses in the toxicological literature Reg Toxicol Pharm 61 73-626
  • [10] Toussanint JF(2022)Hormesis and neuro stem cells Free Rad Biol Med 178 314-302