Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition

被引：0
作者：
Yi-ming Ma
Yan-min Peng
Qiong-hua Zhu
An-hui Gao
Bo Chao
Qiao-jun He
Jia Li
You-hong Hu
Yu-bo Zhou
机构：
[1] State Key Laboratory of Drug Research,Department of Pharmacology and Toxicology
[2] Shanghai Institute of Materia Medica,undefined
[3] Chinese Academy of Sciences,undefined
[4] State Key Laboratory of Natural and Biomimetic Drugs,undefined
[5] Peking University,undefined
[6] College of Pharmaceutical Sciences,undefined
[7] Zhejiang University,undefined
来源：
Acta Pharmacologica Sinica | 2016年 / 37卷
关键词：
CHOP; LGH00168; ER stress; NF-κB; necroptosis; RIP1; ROS; non-small cell lung cancer A549 cells; cancer xenograft mice;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：1381 / 1390
页数：9
相关论文
共 33 条
  • [1] Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-κB inhibition
    Ma, Yi-ming
    Peng, Yan-min
    Zhu, Qiong-hua
    Gao, An-hui
    Chao, Bo
    He, Qiao-jun
    Li, Jia
    Hu, You-hong
    Zhou, Yu-bo
    ACTA PHARMACOLOGICA SINICA, 2016, 37 (10) : 1381 - 1390
  • [2] Levistolide A Induces Apoptosis via ROS-Mediated ER Stress Pathway in Colon Cancer Cells
    Yang, Yingjuan
    Zhang, Yanhua
    Wang, Lan
    Lee, Shaochin
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 42 (03) : 929 - 938
  • [3] Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway
    Qiu, Jinxia
    Zhang, Tao
    Zhu, Xinying
    Yang, Chao
    Wang, Yaxing
    Zhou, Ning
    Ju, Bingxin
    Zhou, Tianhong
    Deng, Ganzhen
    Qiu, Changwei
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (01)
  • [4] Chamaejasmine Induces Apoptosis in Human Lung Adenocarcinoma A549 Cells through a Ros-Mediated Mitochondrial Pathway
    Yu, Hongyang
    Zhang, Tingting
    Cai, Li
    Qu, Yuanyuan
    Hu, Songliu
    Dong, Guanglu
    Guan, Rongwei
    Xu, Xiangying
    Xing, Lina
    MOLECULES, 2011, 16 (10): : 8165 - 8180
  • [5] Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation
    Bo, Su
    Lai, Jing
    Lin, Honyu
    Luo, Xue
    Zeng, Yiqiong
    Du, Tianying
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021, 73 (08) : 1101 - 1108
  • [6] Synergistic effects of particulate matter (PM10) and SO2 on human non-small cell lung cancer A549 via ROS-mediated NF-κB activation
    Yun, Yang
    Gao, Rui
    Yue, Huifeng
    Li, Guangke
    Zhu, Na
    Sang, Nan
    JOURNAL OF ENVIRONMENTAL SCIENCES, 2015, 31 : 146 - 153
  • [7] Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells
    Wei Chen
    Ping Li
    Yi Liu
    Yu Yang
    Xueting Ye
    Fangyi Zhang
    Hang Huang
    Journal of Experimental & Clinical Cancer Research, 37
  • [8] Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells
    Chen, Wei
    Li, Ping
    Liu, Yi
    Yang, Yu
    Ye, Xueting
    Zhang, Fangyi
    Huang, Hang
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2018, 37
  • [9] A novel fluorinated thiosemicarbazone derivative-2-(3,4-difluorobenzylidene) hydrazinecarbothioamide induces apoptosis in human A549 lung cancer cells via ROS-mediated mitochondria-dependent pathway
    Zhao, Yue
    Guo, Chuanlong
    Wang, Lijun
    Wang, Shuaiyu
    Li, Xiangqian
    Jiang, Bo
    Wu, Ning
    Guo, Shuju
    Zhang, Renshuai
    Liu, Kun
    Shi, Dayong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 491 (01) : 65 - 71
  • [10] Parthenium hysterophorus mediated inflammation and hyper-responsiveness via NF-κB pathway in human A549 lung cancer cell line
    Kaur, Mandeep
    Gupta, Kunj Bihari
    Thakur, Shweta
    Kaur, Sukhchain
    Dhiman, Monisha
    ENVIRONMENTAL TOXICOLOGY, 2020, 35 (11) : 1241 - 1250
1234