Merging structural biology with chemical biology: Structural Chemistry at Eskitis

被引：0
作者：
Andreas Hofmann
Conan K. Wang
Asiah Osman
David Camp
机构：
[1] Structural Chemistry Program,
[2] Eskitis Institute for Cell and Molecular Therapies,undefined
[3] Griffith University,undefined
[4] Queensland Compound Library,undefined
[5] Eskitis Institute for Cell and Molecular Therapies,undefined
[6] Griffith University,undefined
来源：
Structural Chemistry | 2010年 / 21卷
关键词：
Molecular mechanisms; Protein crystallography; Protein structure–function; Rational drug design;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review introduces the Structural Chemistry Program at Griffith University’s Eskitis Institute, and provides a brief overview over its current and future research portfolio. Capitalising on the co-location with the Queensland Compound Library (QCL), Australia’s only small molecule repository, our laboratory investigates the structure and function of proteins with the aim of learning about their molecular mechanisms. Consequently, these studies also feed into drug discovery and design. The thematic focus of our Program is on proteins involved in infection, inflammation and neurological diseases, and this review highlights a few of our recent research efforts in this area.
引用
收藏
页码：1117 / 1129
页数：12
相关论文
共 356 条
[1]  
Hofmann A(2002)PCSB—a program collection for structural biology and biophysical chemistry Bioinformatics 18 209-210
[2]  
Wlodawer A(2008)ACDP—a Java application for data processing and analysis of protein circular dichroism spectra J Appl Crystallogr 42 137-139
[3]  
Hofmann A(2004)Chemical space and biology Nature 432 824-828
[4]  
Dobson CM(2005)Creating small-molecule-dependent switches to modulate biological functions Chem Biol 12 151-161
[5]  
Buskirk AR(2004)Exploring biology with small organic molecules Nature 432 846-854
[6]  
Liu DR(1996)The art and practice of structure-based drug design: a molecular modeling perspective Med Res Rev 16 3-50
[7]  
Stockwell BR(2003)Diversity-oriented synthesis; a challenge for synthetic chemists Org Biomol Chem 1 3867-3870
[8]  
Bohacek RS(2007)Natural products as sources of new drugs over the last 25 years J Nat Prod 70 461-477
[9]  
McMartin C(1997)Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv Drug Deliv Rev 23 3-25
[10]  
Guida WC(2004)Drug-like properties: guiding principles for design-or chemical prejudice? Drug Discov Today Technol 1 189-195
12345678910