Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants

被引：0
作者：
Yue Jiao
Yuzhou Zhang
Yu-Xian Zhu
机构：
[1] Peking University,State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences
[2] Ministry of Agriculture,Center for Science and Technology Development
来源：
Science China Life Sciences | 2016年 / 59卷
关键词：
repressor of ; -1; DNA repair; stem cell niche;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
BARD1 (BRCA1 associated RING domain protein 1), as an important animal tumor suppressor gene associated with many kinds of cancers, has been intensively studied for decades. Surprisingly, homolog of BARD1 was found in plants and it was renamed AtROW1 (repressor of Wuschel-1) according to its extremely important function with regard to plant stem cell homeostasis. Although great advances have been made in human BARD1, the function of this animal tumor-suppressor like gene in plant is not well studied and need to be further elucidated. Here, we review and summarize past and present work regarding this protein. Apart from its previously proposed role in DNA repair, recently it is found essential for shoot and root stem cell development and differentiation in plants. The study of AtROW1 in plant may provide an ideal model for further elucidating the functional mechanism of BARD1 in mammals.
引用
收藏
页码：825 / 831
页数：6
相关论文
共 282 条
  • [1] Ade J.(1999)Four mismatch repair paralogues coexist in Mol Gen Genet 262 239-249
  • [2] Belzile F.(2002): AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2 Curr Opin Genet Dev 12 86-91
  • [3] Philippe H.(2006)The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity Trends Biochem Sci 31 35-40
  • [4] Doutriaux M.P.(2004)The PHD finger, a nuclear protein-interaction domain Chromosoma 113 197-203
  • [5] Baer R.(2010)Meiotic defects in the Nucleic Acids Res 39 146-154
  • [6] Ludwig T.(2006) rad50 mutant point to conservation of the MRX complex function in early stages of meiotic recombination Biochem Soc Trans 34 633-645
  • [7] Bienz M.(2010)BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Dev Cell 18 841-853
  • [8] Bleuyard J.Y.(2010)Cellular functions of the BRCA tumour-suppressor proteins Environ Mol Mutagen 51 500-507
  • [9] Gallego M.E.(1996)Transcriptional control of a plant stem cell niche J Biol Chem 271 32863-32868
  • [10] White C.I.(2009)Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair EMBO J 28 621-631
12345678910